PX-866
|
- $65 - $905
- Product name: PX-866
- CAS: 502632-66-8
- MF: C29H35NO8
- MW: 525.59
- EINECS:
- MDL Number:MFCD11840616
- Synonyms:(1E,4S,4aR,5R,6aS,9aR)-5-(Acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4,4a,5,6,6a,8,9,9a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,7,10(1H)-trione;(2R,3S,6Z,11R,15S,17R)-6-{[bis(prop-2-en-1-yl)aMino]Methylidene}-8-hydroxy-3-(MethoxyMethyl)-2,15-diMethyl-5,9,14-trioxo-4-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(10),7-dien-17-yl acetate;Sonolisib;(2R,3S,6Z,11R,15S,17R)-6-{[bis(prop-2-en-1-yl)aMino]Methylidene}-8-hydroxy-3-(MethoxyMethyl)-2,15-diMethyl-5,9,14-trioxo-4-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(10),7-dien-17-yl;PX-866;Acetic acid (1S,4E,10R,11R,13S,14R)-[4-diallylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester;PX-866 (Sonolisib);DJM-166
16 prices
Selected condition：
Brand
- ApexBio Technology
- Apolloscientific
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 5mg
- 10mg
- ManufacturerApexBio Technology
- Product numberC3271
- Product descriptionPX866
- Packaging1mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3271
- Product descriptionPX866
- Packaging5mg
- Price$348
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3271
- Product descriptionPX866
- Packaging10mg
- Price$573
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIP1009
- Product descriptionPX-866
- Packaging5mg
- Price$167
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545881
- Product descriptionPX-866 >98%
- Packaging1mg
- Price$168.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545881
- Product descriptionPX-866 >98%
- Packaging5mg
- Price$299.2
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBP162743
- Product descriptionPX 866
- Packaging5mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13645
- Product descriptionPX 866 ≥98%
- Packaging1mg
- Price$73
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13645
- Product descriptionPX 866 ≥98%
- Packaging5mg
- Price$306
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13645
- Product descriptionPX 866 ≥98%
- Packaging10mg
- Price$502
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0002501
- Product descriptionSonolisib 99.49%
- Packaging1mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0002501
- Product descriptionSonolisib 99.49%
- Packaging5mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number66856
- Product descriptionPX-866
- Packaging5mg
- Price$740
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number66856
- Product descriptionPX-866
- Packaging10mg
- Price$905
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberP840390
- Product descriptionPX-866
- Packaging1mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberP840390
- Product descriptionPX-866
- Packaging10mg
- Price$445
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ApexBio Technology | C3271 | PX866 | 1mg | $82 | 2021-12-16 | Buy |
| ApexBio Technology | C3271 | PX866 | 5mg | $348 | 2021-12-16 | Buy |
| ApexBio Technology | C3271 | PX866 | 10mg | $573 | 2021-12-16 | Buy |
| Apolloscientific | BIP1009 | PX-866 | 5mg | $167 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545881 | PX-866 >98% | 1mg | $168.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545881 | PX-866 >98% | 5mg | $299.2 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BP162743 | PX 866 | 5mg | $195 | 2021-12-16 | Buy |
| Cayman Chemical | 13645 | PX 866 ≥98% | 1mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 13645 | PX 866 ≥98% | 5mg | $306 | 2024-03-01 | Buy |
| Cayman Chemical | 13645 | PX 866 ≥98% | 10mg | $502 | 2024-03-01 | Buy |
| ChemScene | CS-0002501 | Sonolisib 99.49% | 1mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-0002501 | Sonolisib 99.49% | 5mg | $420 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 66856 | PX-866 | 5mg | $740 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 66856 | PX-866 | 10mg | $905 | 2021-12-16 | Buy |
| TRC | P840390 | PX-866 | 1mg | $65 | 2021-12-16 | Buy |
| TRC | P840390 | PX-866 | 10mg | $445 | 2021-12-16 | Buy |
Properties
Boiling point :651.4±55.0 °C(Predicted)
Density :1.28
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :solid
pka :8.35±0.70(Predicted)
color :Orange
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
CAS DataBase Reference :502632-66-8
Density :1.28
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :solid
pka :8.35±0.70(Predicted)
color :Orange
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
CAS DataBase Reference :502632-66-8
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
PX 866 is a ring-opened analog of wortmannin that potently and irreversibly inhibits PI3K (IC50 = 0.1-88 nM). It less potently blocks the activity of mammalian target of rapamycin (mTOR, IC50 = 3.1 μM). PX 866 exhibits single agent in vivo anti-tumor activity and increases the anti-tumor effects of cisplatin and radiation treatment. In cancer cells grown in three-dimensional cultures, PX 866 reduces cell growth and motility without causing cytotoxicity. Consistent with having cytostatic effects, PX 866 dosing is associated with prolonged stable disease in cancer patients.Related product price
- 115104-28-4
$32-860 - Imatinib mesylate
$5-1600 - CYCLOPAMINE
$23-2189