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ChemicalBook >> CAS DataBase List >> INDIRUBIN-3'-MONOXIME

INDIRUBIN-3'-MONOXIME

INDIRUBIN-3'-MONOXIME price.
  • $48 - $2100
  • Product name: INDIRUBIN-3'-MONOXIME
  • CAS: 160807-49-8
  • MF: C16H11N3O2
  • MW: 277.28
  • EINECS:
  • MDL Number:MFCD02683594
  • Synonyms:3-[1,3-DIHYDRO-3-(HYDROXYIMINO)-2H-INDOL-2-YLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE;INDIRUBIN-3'-MONOXIME;INDIRUBIN-3'-OXIME;Indirubine-3'-oxime;INDIRUBIN-3’-MONOOXIME;Indirubin-3;3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one;Indirubin-3-monoxime - CAS 160807-49-8 - Calbiochem
36 prices
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Brand
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
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Package
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  • 2mg
  • 1mg
  • 50
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  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number1800AH
  • Product descriptionIndirubin-3?-monoxime
  • Packaging25mg
  • Price$365
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67459
  • Product descriptionIndirubin-3'-oxime, 98%
  • Packaging5mg
  • Price$180.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67459
  • Product descriptionIndirubin-3'-oxime, 98%
  • Packaging10mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA738539
  • Product description3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one 98%
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA738539
  • Product description3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one 98%
  • Packaging10mg
  • Price$146
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA738539
  • Product description3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one 98%
  • Packaging25mg
  • Price$247
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA738539
  • Product description3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one 98%
  • Packaging50mg
  • Price$369
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000132
  • Product descriptionIndirubin-3?-monoxime 95.00%
  • Packaging5MG
  • Price$647.96
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000132
  • Product descriptionIndirubin-3?-monoxime 95.00%
  • Packaging10MG
  • Price$798
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000132
  • Product descriptionIndirubin-3?-monoxime 95.00%
  • Packaging50MG
  • Price$1127.86
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6865
  • Product descriptionIndirubin-3'-oxime
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6865
  • Product descriptionIndirubin-3'-oxime
  • Packaging10mg
  • Price$173
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6865
  • Product descriptionIndirubin-3'-oxime
  • Packaging50mg
  • Price$693
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611725
  • Product descriptionIndirubin-3?-monoxime
  • Packaging10mg
  • Price$248.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611725
  • Product descriptionIndirubin-3?-monoxime
  • Packaging50mg
  • Price$544
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13314
  • Product descriptionIndirubin-3?-monoxime ≥98%
  • Packaging1mg
  • Price$48
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1800AH Indirubin-3?-monoxime 25mg $365 2021-12-16 Buy
Alfa Aesar J67459 Indirubin-3'-oxime, 98% 5mg $180.65 2024-03-01 Buy
Alfa Aesar J67459 Indirubin-3'-oxime, 98% 10mg $200 2021-12-16 Buy
Ambeed A738539 3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one 98% 5mg $105 2021-12-16 Buy
Ambeed A738539 3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one 98% 10mg $146 2021-12-16 Buy
Ambeed A738539 3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one 98% 25mg $247 2021-12-16 Buy
Ambeed A738539 3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one 98% 50mg $369 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000132 Indirubin-3?-monoxime 95.00% 5MG $647.96 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000132 Indirubin-3?-monoxime 95.00% 10MG $798 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000132 Indirubin-3?-monoxime 95.00% 50MG $1127.86 2021-12-16 Buy
ApexBio Technology B6865 Indirubin-3'-oxime 5mg $110 2021-12-16 Buy
ApexBio Technology B6865 Indirubin-3'-oxime 10mg $173 2021-12-16 Buy
ApexBio Technology B6865 Indirubin-3'-oxime 50mg $693 2021-12-16 Buy
Biorbyt Ltd orb611725 Indirubin-3?-monoxime 10mg $248.2 2021-12-16 Buy
Biorbyt Ltd orb611725 Indirubin-3?-monoxime 50mg $544 2021-12-16 Buy
Cayman Chemical 13314 Indirubin-3?-monoxime ≥98% 1mg $48 2024-03-01 Buy

Properties

Melting point :247-249°C
Boiling point :532.2±50.0 °C(Predicted)
Density :1.50
storage temp. :room temp
solubility :DMSO: >10 mg/mL
form :solid
pka :8.66±0.20(Predicted)
color :Dark red or brown
Stability :Light Sensitive
CAS DataBase Reference :160807-49-8

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Indirubin-3’-oxime is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 22 nM). As GSK3β phosphorylates tau protein, indirubin-3’-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer’s disease-relevant sites. It also inhibits cyclin-dependent kinases (CDKs) at higher concentrations, including Cdk1/cyclin B (IC50 = 180 nM), Cdk2/cyclin A (IC50 ~500 nM), Cdk2/cyclin E (IC50 = 250nM), Cdk4/cyclin D1 (IC50 = 3.3 μM) and Cdk5/p35 (IC50 = 100 nM). Indirubin-3’-oxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.

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