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ChemicalBook >> CAS DataBase List >> HA-14-1

HA-14-1

HA-14-1 price.
  • $32 - $199
  • Product name: HA-14-1
  • CAS: 927635-64-1
  • MF: C17H17BrN2O5
  • MW: 409.24
  • EINECS:
  • MDL Number:
  • Synonyms:4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester;(αR,4R)-rel-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacid,ethylester
4 prices
Selected condition:
Brand
  • Cayman Chemical
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • ManufacturerCayman Chemical
  • Product number14876
  • Product descriptionHA 14-1
  • Packaging5mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14876
  • Product descriptionHA 14-1
  • Packaging10mg
  • Price$61
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14876
  • Product descriptionHA 14-1
  • Packaging25mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14876
  • Product descriptionHA 14-1
  • Packaging50mg
  • Price$199
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 14876 HA 14-1 5mg $32 2024-03-01 Buy
Cayman Chemical 14876 HA 14-1 10mg $61 2024-03-01 Buy
Cayman Chemical 14876 HA 14-1 25mg $139 2024-03-01 Buy
Cayman Chemical 14876 HA 14-1 50mg $199 2024-03-01 Buy

Properties

Boiling point :535.1±50.0 °C(Predicted)
Density :1.480±0.06 g/cm3(Predicted)
solubility :DMF: 5 mg/ml; DMSO: 16 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:9): 0.1 mg/ml
form :A crystalline solid
pka :3.13±0.40(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 μM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3.1 It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W.2 HA-14-1 has been shown to induce apoptosis of human acute myeloid leukemia (HL-60) cells (50 μM induces 90% loss of viability).1