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ChemicalBook >> CAS DataBase List >>HA-14-1

HA-14-1

CAS No.
927635-64-1
Chemical Name:
HA-14-1
Synonyms
4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester;(αR,4R)-rel-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacid,ethylester
CBNumber:
CB34814675
Molecular Formula:
C17H17BrN2O5
Molecular Weight:
409.24
MDL Number:
MOL File:
927635-64-1.mol
Last updated:2023-05-04 17:34:43

HA-14-1 Properties

Boiling point 535.1±50.0 °C(Predicted)
Density 1.480±0.06 g/cm3(Predicted)
solubility DMF: 5 mg/ml; DMSO: 16 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:9): 0.1 mg/ml
form A crystalline solid
pka 3.13±0.40(Predicted)

HA-14-1 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14876 HA 14-1 927635-64-1 5mg $32 2024-03-01 Buy
Cayman Chemical 14876 HA 14-1 927635-64-1 10mg $61 2024-03-01 Buy
Cayman Chemical 14876 HA 14-1 927635-64-1 25mg $139 2024-03-01 Buy
Cayman Chemical 14876 HA 14-1 927635-64-1 50mg $199 2024-03-01 Buy
Product number Packaging Price Buy
14876 5mg $32 Buy
14876 10mg $61 Buy
14876 25mg $139 Buy
14876 50mg $199 Buy

HA-14-1 Chemical Properties,Uses,Production

Description

HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 μM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3.1 It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W.2 HA-14-1 has been shown to induce apoptosis of human acute myeloid leukemia (HL-60) cells (50 μM induces 90% loss of viability).1

Definition

ChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.

References

1. Wang, J.L., Liu, D., Zhang, Z.J., et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells Proc. Natl. Acad. Sci. USA 97(13),7124-7129(2000).
2. Azmi, A.S., and Mohammad, R.M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy J. Cell Physiol. 218(1),13-21(2009).

HA-14-1 Preparation Products And Raw materials

Raw materials

Preparation Products

HA-14-1 Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19699 58
4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester (αR,4R)-rel-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacid,ethylester 927635-64-1