GSK1349572
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- $50 - $6930
- Product name: GSK1349572
- CAS: 1051375-16-6
- MF: C20H19F2N3O5
- MW: 419.38
- EINECS:
- MDL Number:MFCD20488027
- Synonyms:Dolutegravir API;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide Dolutegravir (GSK1349572);GSK1349572, S-349572, GSK572;(4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;Dolutegravir, >=98%;Dolutegravir free acid;GSK1349572
31 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
Package
- 2mg
- 2.5mg
- 5MG
- 10mg
- 20mg
- 25mg
- 50mg
- 100MG
- 200mg
- 250mg
- 500mg
- 1G
- 1000mg
- 5x1ml
- 100g
- ManufacturerAK Scientific
- Product numberX7595
- Product descriptionDolutegravir
- Packaging200mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013713
- Product descriptionDOLUTEGRAVIR 95.00%
- Packaging5MG
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013713
- Product descriptionDOLUTEGRAVIR 95.00%
- Packaging100MG
- Price$2310
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013713
- Product descriptionDOLUTEGRAVIR 95.00%
- Packaging1G
- Price$6930
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4074
- Product descriptionS/GSK1349572
- Packaging100mg
- Price$941
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4074
- Product descriptionS/GSK1349572
- Packaging50mg
- Price$608
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60431
- Product descriptionDolutegravir(GSK1349572) ≥98%
- Packaging20mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2855
- Product descriptionDolutegravir-GSK1349572|Soltegravir|Tivicay 99%
- Packaging5mg
- Price$148.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180971
- Product descriptionDolutegravir (GSK1349572) >98%
- Packaging100mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180971
- Product descriptionDolutegravir (GSK1349572) >98%
- Packaging250mg
- Price$1431.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180971
- Product descriptionDolutegravir (GSK1349572) >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22191
- Product descriptionDolutegravir ≥98%
- Packaging5mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22191
- Product descriptionDolutegravir ≥98%
- Packaging10mg
- Price$222
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22191
- Product descriptionDolutegravir ≥98%
- Packaging25mg
- Price$521
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22191
- Product descriptionDolutegravir ≥98%
- Packaging50mg
- Price$866
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM328252
- Product description(3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide 95%+
- Packaging100g
- Price$2530
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7595 | Dolutegravir | 200mg | $850 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013713 | DOLUTEGRAVIR 95.00% | 5MG | $330 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013713 | DOLUTEGRAVIR 95.00% | 100MG | $2310 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013713 | DOLUTEGRAVIR 95.00% | 1G | $6930 | 2021-12-16 | Buy |
| ApexBio Technology | A4074 | S/GSK1349572 | 100mg | $941 | 2021-12-16 | Buy |
| ApexBio Technology | A4074 | S/GSK1349572 | 50mg | $608 | 2021-12-16 | Buy |
| Arctom | CFN60431 | Dolutegravir(GSK1349572) ≥98% | 20mg | $208 | 2021-12-16 | Buy |
| Axon Medchem | Axon2855 | Dolutegravir-GSK1349572|Soltegravir|Tivicay 99% | 5mg | $148.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180971 | Dolutegravir (GSK1349572) >98% | 100mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180971 | Dolutegravir (GSK1349572) >98% | 250mg | $1431.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180971 | Dolutegravir (GSK1349572) >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Cayman Chemical | 22191 | Dolutegravir ≥98% | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 22191 | Dolutegravir ≥98% | 10mg | $222 | 2024-03-01 | Buy |
| Cayman Chemical | 22191 | Dolutegravir ≥98% | 25mg | $521 | 2024-03-01 | Buy |
| Cayman Chemical | 22191 | Dolutegravir ≥98% | 50mg | $866 | 2024-03-01 | Buy |
| Chemenu | CM328252 | (3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide 95%+ | 100g | $2530 | 2021-12-16 | Buy |
Properties
Melting point :187-189°C
Boiling point :669.0±55.0 °C(Predicted)
Density :1.53
storage temp. :Refrigerator
solubility :DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
pka :4.50±1.00(Predicted)
form :Solid
color :White to Pale Beige
Boiling point :669.0±55.0 °C(Predicted)
Density :1.53
storage temp. :Refrigerator
solubility :DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
pka :4.50±1.00(Predicted)
form :Solid
color :White to Pale Beige
Safety Information
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Description
In August 2013, the US FDA approved dolutegravir (also referred to as S/GSK1349572) for the treatment of HIV-1 infection in adults and children ages 12 years and older in combination with other antiretroviral drugs. Dolutegravir was approved in Canada in November 2013. HIV/AIDS remains a global epidemic with 35 million people infected, including 2.3 million new infections as of 2012. Dolutegravir joins raltegravir and elvitegravir (this chapter of ARMC) as the latest of three FDA-approved HIV integrase strand transfer inhibitors (INSTIs). Dolutegravir was discovered by rational design from a literature diketo acid HIV integrase inhibitor utilizing X-ray coordinates to predict ideal bond angles between the diketone and distal benzyl group. In dolutegravir, the monocyclic component of the reported inhibitor was replaced with the tricyclic carbamoyl pyridone moiety. The researchers postulated that the appropriate arrangement of three oxygens would permit chelation with two magnesium ions in the binding site thus affording improved potency. Ultimately, this arrangement along with further modifications afforded dolutegravir, a potent inhibitor of HIV integrase (IC50=1.7 nM).Related product price
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Suppliers and manufacturers
AFINE CHEMICALS LIMITED
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ATK CHEMICAL COMPANY LIMITED
Lianyungang happen teng technology co., LTD
SHANDONG ZHI SHANG CHEMICAL CO.LTD
