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ChemicalBook >> CAS DataBase List >> GDC-0032

GDC-0032

GDC-0032 price.
  • $37 - $17576
  • Product name: GDC-0032
  • CAS: 1282512-48-4
  • MF: C24H28N8O2
  • MW: 460.53
  • EINECS:
  • MDL Number:MFCD26142641
  • Synonyms:GDC-0032;RG7604/GDC-0032;4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl-1H-pyrazole-1-acetamide;GDC-0032/(RG-7604);2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide;Taselisib;4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide;GDC-0032 4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide
28 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 1mg
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  • 2x5mg
  • 25mg
  • 50mg
  • 200mg
  • 10mM(in 1mL DMSO)
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1202-M001
  • Product descriptionGDC-0032 ≥95%
  • Packaging1mg
  • Price$86
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1202-M005
  • Product descriptionGDC-0032 ≥95%
  • Packaging5mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number9344AF
  • Product descriptionGDC-0032
  • Packaging25mg
  • Price$226
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1047
  • Product descriptionGDC-0032
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1047
  • Product descriptionGDC-0032
  • Packaging10mM(in 1mL DMSO)
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1047
  • Product descriptionGDC-0032
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1047
  • Product descriptionGDC-0032
  • Packaging25mg
  • Price$265
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1047
  • Product descriptionGDC-0032
  • Packaging100mg
  • Price$615
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2927
  • Product descriptionTaselisib-GDC0032|RG7604 99%
  • Packaging5mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2927
  • Product descriptionTaselisib-GDC0032|RG7604 99%
  • Packaging2x5mg
  • Price$154
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181246
  • Product descriptionTaselisib (GDC-0032) >98%
  • Packaging1000mg
  • Price$2395.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181246
  • Product descriptionTaselisib (GDC-0032) >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181246
  • Product descriptionTaselisib (GDC-0032) >98%
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17387
  • Product descriptionGDC-0032 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17387
  • Product descriptionGDC-0032 ≥98%
  • Packaging5mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17387
  • Product descriptionGDC-0032 ≥98%
  • Packaging10mg
  • Price$161
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1202-M001 GDC-0032 ≥95% 1mg $86 2021-12-16 Buy
Adipogen Life Sciences SYN-1202-M005 GDC-0032 ≥95% 5mg $130 2021-12-16 Buy
AK Scientific 9344AF GDC-0032 25mg $226 2021-12-16 Buy
ApexBio Technology B1047 GDC-0032 5mg $80 2021-12-16 Buy
ApexBio Technology B1047 GDC-0032 10mM(in 1mL DMSO) $109 2021-12-16 Buy
ApexBio Technology B1047 GDC-0032 10mg $120 2021-12-16 Buy
ApexBio Technology B1047 GDC-0032 25mg $265 2021-12-16 Buy
ApexBio Technology B1047 GDC-0032 100mg $615 2021-12-16 Buy
Axon Medchem Axon2927 Taselisib-GDC0032|RG7604 99% 5mg $99 2021-12-16 Buy
Axon Medchem Axon2927 Taselisib-GDC0032|RG7604 99% 2x5mg $154 2021-12-16 Buy
Biorbyt Ltd orb181246 Taselisib (GDC-0032) >98% 1000mg $2395.3 2021-12-16 Buy
Biorbyt Ltd orb181246 Taselisib (GDC-0032) >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb181246 Taselisib (GDC-0032) >98% 100mg $690.2 2021-12-16 Buy
Cayman Chemical 17387 GDC-0032 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 17387 GDC-0032 ≥98% 5mg $116 2024-03-01 Buy
Cayman Chemical 17387 GDC-0032 ≥98% 10mg $161 2024-03-01 Buy

Properties

Boiling point :783.3±70.0 °C(Predicted)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in H2O; ≥2.79 mg/mL in EtOH with gentle warming
form :solid
pka :15.54±0.50(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms α, δ, and γ (IC50s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3Kβ. It is over 1,000-fold selective for p100α over other PI3K-like kinases, including DNA-dependent protein kinase catalytic subunits, ATM, and ATR. GDC-0032 has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo, suppressing the growth of tumors in a mouse xenograft model at low drug dose levels.

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