Debromo Hymenialdisine
|
- $110 - $645
- Product name: Debromo Hymenialdisine
- CAS: 75593-17-8
- MF: C11H10N5O2
- MW: 244.2294
- EINECS:
- MDL Number:MFCD04037016
- Synonyms:DEBROMOHYMENIALDISINE;Debromohymenialdesine;Pyrrolo[2,3-c]azepin-8(1H)-one, 4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-, (4Z)-
5 prices
Selected condition：
Brand
- Adipogen Life Sciences
- Cayman Chemical
- TRC
- Usbiological
Package
- 100ug
- 100μg
- 1mg
- 2.5mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0068-C100
- Product descriptionDebromohymenialdisine ≥95%(HPLC)
- Packaging100μg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14873
- Product descriptionDebromohymenialdisine ≥95%
- Packaging100μg
- Price$110
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberD208900
- Product descriptionDebromoHymenialdisine
- Packaging2.5mg
- Price$645
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number007589
- Product descriptionDebromo Hymenialdisine
- Packaging1mg
- Price$623
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number044726
- Product descriptionDebromohymenialdisine
- Packaging100ug
- Price$329
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0068-C100 | Debromohymenialdisine ≥95%(HPLC) | 100μg | $110 | 2021-12-16 | Buy |
| Cayman Chemical | 14873 | Debromohymenialdisine ≥95% | 100μg | $110 | 2024-03-01 | Buy |
| TRC | D208900 | DebromoHymenialdisine | 2.5mg | $645 | 2021-12-16 | Buy |
| Usbiological | 007589 | Debromo Hymenialdisine | 1mg | $623 | 2021-12-16 | Buy |
| Usbiological | 044726 | Debromohymenialdisine | 100ug | $329 | 2021-12-16 | Buy |
Properties
Melting point :>250°C (dec.)
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :DMSO, Methanol
form :Yellow solid.
color :Yellow
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :DMSO, Methanol
form :Yellow solid.
color :Yellow
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2. Debromohymenialdisine (DBH) is a marine sponge alkaloid that inhibits Chk1 and Chk2 (IC50 = 3 and 3.5 μM, respectively), blocking G2 arrest. Because it does not significantly affect the activity of ataxia-telangiectasia mutated (ATM) or ATM-Tad2-related protein, DBH is a useful tool for studying the roles of Chk1 and Chk2 in DNA repair and cell cycle regulation. DBH also inhibits MAP kinase kinase 1 (IC50 = 881 nM), glycogen synthase kinase 3β (IC50 = 1.39 μM), cyclin-dependent kinase 5/p25 (IC50 = 9.12 μM), protein tyrosine kinase 6 (IC50 = 0.6 μM), and other kinases largely unrelated to DNA damage/repair and cell cycling.More related product prices
CHK2 INHIBITOR IIRelated product price
- CHK2 INHIBITOR II
$32-1500
Suppliers and manufacturers
Aladdin Scientific
J & K SCIENTIFIC LTD.
Chemsky（shanghai）International Co.,Ltd.
BOC Sciences
Shanghai EFE Biological Technology Co., Ltd.
Guangdong wengjiang Chemical Reagent Co., Ltd.
Shenzhen Polymeri Biochemical Technology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Energy Chemical
Jinan Jiuli Biotechnology Co. , Ltd.