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ChemicalBook >> CAS DataBase List >> AZD 9668

AZD 9668

AZD 9668 price.
  • $44 - $2986.9
  • Product name: AZD 9668
  • CAS: 848141-11-7
  • MF: C25H22F3N5O4S
  • MW: 545.53
  • EINECS:
  • MDL Number:MFCD26960961
  • Synonyms:Alvelestat;AZD 9668;AZD9668;AZD-9668;Avelestat (AZD9668);6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide;Avelestat;Alvelestat (AZD9668)
32 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • 1000mg
  • ManufacturerAK Scientific
  • Product number8535DG
  • Product descriptionAlvelestat
  • Packaging1mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number8535DG
  • Product descriptionAlvelestat
  • Packaging5mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number8535DG
  • Product descriptionAlvelestat
  • Packaging25mg
  • Price$572
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1037
  • Product descriptionAlvelestat
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1037
  • Product descriptionAlvelestat
  • Packaging10mM(in 1mL DMSO)
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1037
  • Product descriptionAlvelestat
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1037
  • Product descriptionAlvelestat
  • Packaging25mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1037
  • Product descriptionAlvelestat
  • Packaging50mg
  • Price$590
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1037
  • Product descriptionAlvelestat
  • Packaging100mg
  • Price$920
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180938
  • Product descriptionAlvelestat (AZD9668) >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180938
  • Product descriptionAlvelestat (AZD9668) >98%
  • Packaging250mg
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180938
  • Product descriptionAlvelestat (AZD9668) >98%
  • Packaging1000mg
  • Price$2986.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA104198
  • Product descriptionAlvelestat
  • Packaging1mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA104198
  • Product descriptionAlvelestat
  • Packaging2mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA104198
  • Product descriptionAlvelestat
  • Packaging5mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA104198
  • Product descriptionAlvelestat
  • Packaging10mg
  • Price$520
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 8535DG Alvelestat 1mg $147 2021-12-16 Buy
AK Scientific 8535DG Alvelestat 5mg $218 2021-12-16 Buy
AK Scientific 8535DG Alvelestat 25mg $572 2021-12-16 Buy
ApexBio Technology B1037 Alvelestat 5mg $105 2021-12-16 Buy
ApexBio Technology B1037 Alvelestat 10mM(in 1mL DMSO) $156 2021-12-16 Buy
ApexBio Technology B1037 Alvelestat 10mg $180 2021-12-16 Buy
ApexBio Technology B1037 Alvelestat 25mg $360 2021-12-16 Buy
ApexBio Technology B1037 Alvelestat 50mg $590 2021-12-16 Buy
ApexBio Technology B1037 Alvelestat 100mg $920 2021-12-16 Buy
Biorbyt Ltd orb180938 Alvelestat (AZD9668) >98% 100mg $838.1 2021-12-16 Buy
Biorbyt Ltd orb180938 Alvelestat (AZD9668) >98% 250mg $1504.5 2021-12-16 Buy
Biorbyt Ltd orb180938 Alvelestat (AZD9668) >98% 1000mg $2986.9 2021-12-16 Buy
Biosynth Carbosynth FA104198 Alvelestat 1mg $125 2021-12-16 Buy
Biosynth Carbosynth FA104198 Alvelestat 2mg $200 2021-12-16 Buy
Biosynth Carbosynth FA104198 Alvelestat 5mg $300 2021-12-16 Buy
Biosynth Carbosynth FA104198 Alvelestat 10mg $520 2021-12-16 Buy

Properties

Melting point :207-209°C
Boiling point :780.4±60.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly)
pka :11.00±0.20(Predicted)
form :Solid
color :White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

AZD 9668 is an orally bioavailable inhibitor of neutrophil elastase (IC50 = 12 nM for the human enzyme). It is greater than 600-fold selective for neutrophil elastase over other serine proteases, including human proteinase-3 and cathepsin G, bovine trypsin and chymotrypsin, and porcine pancreatic elastase. AZD 9668 inhibits neutrophil elastase activity in zymosan-stimulated isolated whole blood and in cell-associated assays (IC50s = 46 and 48 nM, respectively). It decreases the number of neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of smoke-induced airway inflammation when administered at a dose of 6 mg/kg. AZD 9668 also prevents airspace enlargement and small airway remodeling in a guinea pig model of chronic smoke-induced inflammation and emphysema.