Alvelestat NEW
| Price | $30 | $38 | $54 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Alvelestat | CAS No.: 848141-11-7 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Alvelestat |
| 描述 | Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity. |
| 體外活性 | In a mouse model of (smoke)-induced airway inflammation, AZD9668 significantly reduced the number of (neutrophils) in the bronchoalveolar lavage (BAL) and the level of BAL IL-1β. Oral administration of AZD9668 in both mice and rats was able to inhibit (NE)-induced lung injury. |
| 體內(nèi)活性 | In whole blood stimulated by yeast polysaccharide, AZD9668 effectively inhibits NE (NE) activity in the supernatant of antigen-challenged cells and on the surface of stimulated polymorphonuclear cells. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 40 mg/mL (73.32 mM) |
| 關(guān)鍵字 | Elastase | AZD 9668 | Inhibitor | AZD-9668 | inhibit | Alvelestat |
| 相關(guān)產(chǎn)品 | PMSF | Nafamostat mesylate | Diminazene Aceturate | AEBSF hydrochloride | 2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one | Leupeptin Hemisulfate | Ceritinib | Aprotinin | Sivelestat | 4-Aminobenzamidine dihydrochloride | 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- | Benzamidine hydrochloride |
| 相關(guān)庫 | 高選擇性抑制劑庫 | 表型篩選靶點(diǎn)鑒定庫 | 經(jīng)典已知活性庫 | ReFRAME 相關(guān)化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 口服活性化合物庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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