AZD 1480
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- $37 - $2158.7
- Product name: AZD 1480
- CAS: 935666-88-9
- MF: C14H14ClFN8
- MW: 348.77
- EINECS:
- MDL Number:MFCD16038904
- Synonyms:5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;AZD 1480;(S)-5-chloro-N4-(5-Methyl-1H-pyrazol-3-yl)-N2-(1-(5-MethylpyriMidin-2-yl)ethyl)pyriMidine-2,4-diaMine;(S)-5-chloro-N2-(1-(5-fluoropyriMidin-2-yl)ethyl)-N4-(5-Methyl-1H-pyrazol-3-yl)pyriMidine-2,4-diaMine;5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine AZD 1480;AZD 1480 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;AZD1480, >=98%;AZD1480;AZD1480;AZD 1480
35 prices
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Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- AvaChem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1MG
- 5mg
- 10mg
- 25mg
- 50MG
- 100mg
- 200mg
- 10
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5710
- Product descriptionAZD1480
- Packaging100mg
- Price$1174
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000831
- Product descriptionAZD-1480 95.00%
- Packaging1MG
- Price$140.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000831
- Product descriptionAZD-1480 95.00%
- Packaging50MG
- Price$2158.7
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4137
- Product descriptionAZD1480
- Packaging200mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0012
- Product descriptionAZD1480 99%
- Packaging50mg
- Price$305
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0012
- Product descriptionAZD1480 99%
- Packaging100mg
- Price$551
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0012
- Product descriptionAZD1480 99%
- Packaging250mg
- Price$986
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2598
- Product descriptionAZD1480
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2598
- Product descriptionAZD1480
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2598
- Product descriptionAZD1480
- Packaging50mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberNC44330
- Product descriptionAZD 1480
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberNC44330
- Product descriptionAZD 1480
- Packaging50mg
- Price$332.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10702
- Product descriptionAZD1480 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10702
- Product descriptionAZD1480 ≥98%
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10702
- Product descriptionAZD1480 ≥98%
- Packaging10mg
- Price$195
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10702
- Product descriptionAZD1480 ≥98%
- Packaging50mg
- Price$670
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5710 | AZD1480 | 100mg | $1174 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000831 | AZD-1480 95.00% | 1MG | $140.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000831 | AZD-1480 95.00% | 50MG | $2158.7 | 2021-12-16 | Buy |
| ApexBio Technology | A4137 | AZD1480 | 200mg | $650 | 2021-12-16 | Buy |
| Apolloscientific | BISN0012 | AZD1480 99% | 50mg | $305 | 2021-12-16 | Buy |
| Apolloscientific | BISN0012 | AZD1480 99% | 100mg | $551 | 2021-12-16 | Buy |
| Apolloscientific | BISN0012 | AZD1480 99% | 250mg | $986 | 2021-12-16 | Buy |
| AvaChem | 2598 | AZD1480 | 5mg | $55 | 2021-12-16 | Buy |
| AvaChem | 2598 | AZD1480 | 10mg | $95 | 2021-12-16 | Buy |
| AvaChem | 2598 | AZD1480 | 50mg | $235 | 2021-12-16 | Buy |
| Biosynth Carbosynth | NC44330 | AZD 1480 | 10mg | $95 | 2021-12-16 | Buy |
| Biosynth Carbosynth | NC44330 | AZD 1480 | 50mg | $332.5 | 2021-12-16 | Buy |
| Cayman Chemical | 10702 | AZD1480 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 10702 | AZD1480 ≥98% | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 10702 | AZD1480 ≥98% | 10mg | $195 | 2024-03-01 | Buy |
| Cayman Chemical | 10702 | AZD1480 ≥98% | 50mg | $670 | 2024-03-01 | Buy |
Properties
Melting point :>205°C (dec.)
Boiling point :575.2±60.0 °C(Predicted)
Density :1.517
storage temp. :-20°C
solubility :Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
form :powder
pka :13.73±0.10(Predicted)
color :white to beige
InChI :InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
InChIKey :PDOQBOJDRPLBQU-QMMMGPOBSA-N
SMILES :C1(N[C@H](C2=NC=C(F)C=N2)C)=NC=C(Cl)C(NC2C=C(C)NN=2)=N1
Boiling point :575.2±60.0 °C(Predicted)
Density :1.517
storage temp. :-20°C
solubility :Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
form :powder
pka :13.73±0.10(Predicted)
color :white to beige
InChI :InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
InChIKey :PDOQBOJDRPLBQU-QMMMGPOBSA-N
SMILES :C1(N[C@H](C2=NC=C(F)C=N2)C)=NC=C(Cl)C(NC2C=C(C)NN=2)=N1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). AZD1480 is a potent JAK2 inhibitor that blocks signaling (IC50 = 58 nM at 5 mM ATP) and proliferation of JAK2-expressing cell lines (GI50 = 60 nM). It is selective for JAK2 over other JAK family members as well as a panel of related kinases. AZD1480 also inhibits the growth of cells expressing the V617F mutant of JAK2 (GI50 = 60 nM). It reversibly blocks JAK2-mediated phosphorylation of STAT3 and STAT5. AZD1480 displays good pharmacokinetics in vivo, inhibits STAT3 and STAT5 activation in vivo, and suppresses tumorigenesis in mouse xenografts harboring constitutive STAT3 activity. In addition to suppressing myeloma cell growth and survival, AZD1480 reduces angiogenesis and metastasis in vitro and in human xenograft tumor models.More related product prices
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Suppliers and manufacturers
career henan chemical co
![5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine](https://img.chemicalbook.com/ProductImageEN/2018-8/small/f4935d30-a38e-4bef-be96-57c345a031ed.jpg)
Wuhan Topule Biopharmaceutical Co., Ltd
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei xin bonus chemical co. LTD
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
$1.00 /1KG
5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine CAS:935666-88-9
5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine CAS:935666-88-9
