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ChemicalBook >> CAS DataBase List >> 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine  hydrate  hydrochloride price.
  • $33 - $1348
  • Product name: 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride
  • CAS: 694433-59-5
  • MF: C20H21N3O2
  • MW: 335.4
  • EINECS:
  • MDL Number:MFCD20926329
  • Synonyms:2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride;SB-505124 hydrate hydrochloride;2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-iMidazol-4-yl)-6-Methylpyridine;2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1- diMethylethyl)-1H-iMidazol-5-yl]-6-Methyl-pyridine;2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine;SB-505124 hydrochloride hydrate;2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine;2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine SB505124
39 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2707AH
  • Product descriptionSB-505124
  • Packaging50mg
  • Price$419
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA114347
  • Product descriptionSB-505124 98+%
  • Packaging1mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA114347
  • Product descriptionSB-505124 98+%
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA114347
  • Product descriptionSB-505124 98+%
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA114347
  • Product descriptionSB-505124 98+%
  • Packaging50mg
  • Price$266
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA114347
  • Product descriptionSB-505124 98+%
  • Packaging100mg
  • Price$395
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA114347
  • Product descriptionSB-505124 98+%
  • Packaging250mg
  • Price$537
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA114347
  • Product descriptionSB-505124 98+%
  • Packaging1g
  • Price$1348
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0007582
  • Product descriptionSB-505124 HYDROCHLORIDE HYDRATE 95.00%
  • Packaging5MG
  • Price$756.58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0007582
  • Product descriptionSB-505124 HYDROCHLORIDE HYDRATE 95.00%
  • Packaging25MG
  • Price$1226.1
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS436193
  • Product descriptionSB-505124 ≥98%
  • Packaging1mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS436193
  • Product descriptionSB-505124 ≥98%
  • Packaging5mg
  • Price$64
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS436193
  • Product descriptionSB-505124 ≥98%
  • Packaging10mg
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60366
  • Product descriptionSB505124 ≥98%
  • Packaging5mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS436193
  • Product descriptionSB-505124 ≥98%
  • Packaging50mg
  • Price$263
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS436193
  • Product descriptionSB-505124 ≥98%
  • Packaging100mg
  • Price$391
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2707AH SB-505124 50mg $419 2021-12-16 Buy
Ambeed A114347 SB-505124 98+% 1mg $33 2021-12-16 Buy
Ambeed A114347 SB-505124 98+% 5mg $65 2021-12-16 Buy
Ambeed A114347 SB-505124 98+% 10mg $110 2021-12-16 Buy
Ambeed A114347 SB-505124 98+% 50mg $266 2021-12-16 Buy
Ambeed A114347 SB-505124 98+% 100mg $395 2021-12-16 Buy
Ambeed A114347 SB-505124 98+% 250mg $537 2021-12-16 Buy
Ambeed A114347 SB-505124 98+% 1g $1348 2021-12-16 Buy
American Custom Chemicals Corporation API0007582 SB-505124 HYDROCHLORIDE HYDRATE 95.00% 5MG $756.58 2021-12-16 Buy
American Custom Chemicals Corporation API0007582 SB-505124 HYDROCHLORIDE HYDRATE 95.00% 25MG $1226.1 2021-12-16 Buy
Arctom AS436193 SB-505124 ≥98% 1mg $33 2021-12-16 Buy
Arctom AS436193 SB-505124 ≥98% 5mg $64 2021-12-16 Buy
Arctom AS436193 SB-505124 ≥98% 10mg $109 2021-12-16 Buy
Arctom CFN60366 SB505124 ≥98% 5mg $138 2021-12-16 Buy
Arctom AS436193 SB-505124 ≥98% 50mg $263 2021-12-16 Buy
Arctom AS436193 SB-505124 ≥98% 100mg $391 2021-12-16 Buy

Properties

Melting point :168 °C
Boiling point :509.7±50.0 °C(Predicted)
Density :1.202
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >10mg/mL
pka :11.26±0.10(Predicted)
form :powder
color :yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB-505124 inhibits the TGF-β1 receptor serine/threonine kinase ALK5 with an IC50 value of 47 nM. Though it is a less potent antagonist of ALK4 (IC50 = 129 nM) and ALK7, SB-505124 selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK7-dependent activation of downstream SMAD2 and SMAD3 and TGF-β–induced MAP kinase pathway components without altering ALK1-3 or ALK6-induced SMAD signaling. In an assay determining in vitro phosphorylation of SMAD3, SB-505124 is more potent than SB-431452 with IC50 values of 47 versus 94 nM, respectively.