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ChemicalBook >> CAS DataBase List >> GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide

GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide

GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide price.
  • $57 - $1800
  • Product name: GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide
  • CAS: 660868-91-7
  • MF: C22H18F3N3O4S
  • MW: 477.46
  • EINECS:200-258-5
  • MDL Number:MFCD09971143
  • Synonyms:GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide;GW843682X;3-(2-(Trifluoromethyl)benzyloxy)-5-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide;Polo-like Kinase Inhibitor III;5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide;5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide;GW843682;5-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide
18 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 10
  • 1
  • 500μg
  • 1MG
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000123
  • Product descriptionGW 843682X 95.00%
  • Packaging1MG
  • Price$617.3
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3456
  • Product descriptionGW843682X
  • Packaging10mg
  • Price$213
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1131
  • Product descriptionGW843682X 99%
  • Packaging5mg
  • Price$82.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number28759
  • Product descriptionGW843682X
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28759
  • Product descriptionGW843682X
  • Packaging5mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28759
  • Product descriptionGW843682X
  • Packaging10mg
  • Price$249
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0070
  • Product descriptionGW843682X 99.84%
  • Packaging5mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0070
  • Product descriptionGW843682X 99.84%
  • Packaging10mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0070
  • Product descriptionGW843682X 99.84%
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8609
  • Product descriptionGW843682X >98%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8609
  • Product descriptionGW843682X >98%
  • Packaging250mg
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8609
  • Product descriptionGW843682X >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number528284
  • Product descriptionPolo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem
  • Packaging500μg
  • Price$140
  • Updated2023-01-07
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberG2171
  • Product descriptionGW843682X ≥98% (HPLC), solid
  • Packaging1mg
  • Price$178
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberG2171
  • Product descriptionGW843682X ≥98% (HPLC), solid
  • Packaging5mg
  • Price$567
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number2977
  • Product descriptionGW843682X ≥98%(HPLC)
  • Packaging1
  • Price$101
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation KIN0000123 GW 843682X 95.00% 1MG $617.3 2021-12-16 Buy
ApexBio Technology A3456 GW843682X 10mg $213 2021-12-16 Buy
Axon Medchem Axon1131 GW843682X 99% 5mg $82.5 2021-12-16 Buy
Cayman Chemical 28759 GW843682X 1mg $57 2024-03-01 Buy
Cayman Chemical 28759 GW843682X 5mg $139 2024-03-01 Buy
Cayman Chemical 28759 GW843682X 10mg $249 2024-03-01 Buy
ChemScene CS-0070 GW843682X 99.84% 5mg $84 2021-12-16 Buy
ChemScene CS-0070 GW843682X 99.84% 10mg $144 2021-12-16 Buy
ChemScene CS-0070 GW843682X 99.84% 50mg $540 2021-12-16 Buy
DC Chemicals DC8609 GW843682X >98% 100mg $450 2021-12-16 Buy
DC Chemicals DC8609 GW843682X >98% 250mg $900 2021-12-16 Buy
DC Chemicals DC8609 GW843682X >98% 1g $1800 2021-12-16 Buy
Sigma-Aldrich 528284 Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem 500μg $140 2023-01-07 Buy
Sigma-Aldrich G2171 GW843682X ≥98% (HPLC), solid 1mg $178 2024-03-01 Buy
Sigma-Aldrich G2171 GW843682X ≥98% (HPLC), solid 5mg $567 2024-03-01 Buy
Tocris 2977 GW843682X ≥98%(HPLC) 1 $101 2021-12-16 Buy

Properties

Boiling point :609.1±65.0 °C(Predicted)
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
pka :15.03±0.50(Predicted)
form :solid
color :off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Polo-like Kinase Inhibitor III (GW843682X) is a cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against Plk (polo-like kinases) (Ki against Plk1/2/3/4 = 4.8, 3.8, 8.0, and 163 nM , respectively), while exhibiting little or much reduced activity against 39 other commonly studied kinases. Polo-like Kinase Inhibitor III preferentially inhibits the proliferation of a panel of 11 tumor cell lines (IC50 ≤0.7 μM) over normal human diploid fibroblasts (IC50 = 6.14 μM) in culture and is equally potent against the mdr-1-expressing MES-SA/DX5 and its parent non-drug resistant MES-SA uterine sarcoma cell line.

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