GW843682X
Catalog No.
A3456
PLK1/PLK3 inhibitor,potent and selective
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GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). GW843682X displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. GW843682X inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.
| Physical Appearance | Pale yellow solid |
| Storage | Store at -20°C |
| M.Wt | 477.46 |
| Cas No. | 660868-91-7 |
| Formula | C22H18F3N3O4S |
| Synonyms | GW 843682X;GW843682;GW-843682X |
| Solubility | Soluble in DMSO |
| Chemical Name | 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
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