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ChemicalBook >> CAS DataBase List >> N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide

N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide

N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide price.
  • $34 - $1095
  • Product name: N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide
  • CAS: 487020-03-1
  • MF: C20H11N5OS
  • MW: 369.4
  • EINECS:
  • MDL Number:MFCD03286313
  • Synonyms:N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide;HI-TOPK-032;HI-TOPK-32;2-Thiophenecarboxamide, N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)-;HI-TOPK-032 (HI TOPK 032;N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide;HITOPK032,inhibit,HI TOPK 032,TOPK,Inhibitor;HI-TOPK-032, 10 mM in DMSO
20 prices
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Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product numberSYN5181
  • Product descriptionHI-TOPK-32
  • Packaging50mg
  • Price$585
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5640
  • Product descriptionHITOPK032
  • Packaging5mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5640
  • Product descriptionHITOPK032
  • Packaging10mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5640
  • Product descriptionHITOPK032
  • Packaging25mg
  • Price$378
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5640
  • Product descriptionHITOPK032
  • Packaging50mg
  • Price$646
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5640
  • Product descriptionHITOPK032
  • Packaging100mg
  • Price$1095
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19815
  • Product descriptionHI TOPK 032 ≥95%
  • Packaging1mg
  • Price$34
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19815
  • Product descriptionHI TOPK 032 ≥95%
  • Packaging5mg
  • Price$92
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19815
  • Product descriptionHI TOPK 032 ≥95%
  • Packaging10mg
  • Price$150
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6900
  • Product descriptionHI-TOPK-032 99.21%
  • Packaging5mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6900
  • Product descriptionHI-TOPK-032 99.21%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6900
  • Product descriptionHI-TOPK-032 99.21%
  • Packaging25mg
  • Price$234
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6900
  • Product descriptionHI-TOPK-032 99.21%
  • Packaging50mg
  • Price$402
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6900
  • Product descriptionHI-TOPK-032 99.21%
  • Packaging100mg
  • Price$696
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0796
  • Product descriptionHI-TOPK-032 ≥98% (HPLC)
  • Packaging5mg
  • Price$123
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number614849
  • Product descriptionTOPK/PBK Inhibitor, HI-TOPK-032 - CAS 487020-03-1 - Calbiochem A cell-permeable, selective, ATP competitive, reversible inhibitor of T-LAK-cell-originated protein kinase (IC?? = 2 μM).
  • Packaging5MG
  • Price$201
  • Updated2023-06-20
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5181 HI-TOPK-32 50mg $585 2021-12-16 Buy
ApexBio Technology B5640 HITOPK032 5mg $119 2021-12-16 Buy
ApexBio Technology B5640 HITOPK032 10mg $189 2021-12-16 Buy
ApexBio Technology B5640 HITOPK032 25mg $378 2021-12-16 Buy
ApexBio Technology B5640 HITOPK032 50mg $646 2021-12-16 Buy
ApexBio Technology B5640 HITOPK032 100mg $1095 2021-12-16 Buy
Cayman Chemical 19815 HI TOPK 032 ≥95% 1mg $34 2024-03-01 Buy
Cayman Chemical 19815 HI TOPK 032 ≥95% 5mg $92 2024-03-01 Buy
Cayman Chemical 19815 HI TOPK 032 ≥95% 10mg $150 2024-03-01 Buy
ChemScene CS-6900 HI-TOPK-032 99.21% 5mg $72 2021-12-16 Buy
ChemScene CS-6900 HI-TOPK-032 99.21% 10mg $108 2021-12-16 Buy
ChemScene CS-6900 HI-TOPK-032 99.21% 25mg $234 2021-12-16 Buy
ChemScene CS-6900 HI-TOPK-032 99.21% 50mg $402 2021-12-16 Buy
ChemScene CS-6900 HI-TOPK-032 99.21% 100mg $696 2021-12-16 Buy
Sigma-Aldrich SML0796 HI-TOPK-032 ≥98% (HPLC) 5mg $123 2024-03-01 Buy
Sigma-Aldrich 614849 TOPK/PBK Inhibitor, HI-TOPK-032 - CAS 487020-03-1 - Calbiochem A cell-permeable, selective, ATP competitive, reversible inhibitor of T-LAK-cell-originated protein kinase (IC?? = 2 μM). 5MG $201 2023-06-20 Buy

Properties

Boiling point :415.3±45.0 °C(Predicted)
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble3mg/mL, clear (warmed)
pka :9.32±0.46(Predicted)
form :powder
color :orange-brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

HI TOPK 032 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK), blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 μM and providing complete inhibition at 5 μM. It also inhibits checkpoint kinase 1 (Chk1; IC50 = 9.6 μM). In addition, HI TOPK 032 inhibits MEK1, achieving 40% inhibition at 5 μM, but it does not alter the activities of ERK1, JNK1, or p38 MAPK at 2 μM. HI TOPK 032 decreases the growth of colon cancer and glioma initiating cells in vitro and suppresses tumor growth in vivo.