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ChemicalBook >> CAS DataBase List >> THYROID HORMONE RECEPTOR ANTAGONIST, 1-850

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 price.
  • $45 - $464
  • Product name: THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
  • CAS: 251310-57-3
  • MF: C21H20F3N5O4
  • MW: 463.41
  • EINECS:
  • MDL Number:MFCD06411459
  • Synonyms:THYROID HORMONE RECEPTOR ANTAGONIST, 1-850;TR ANTAGONIST 1-850;2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE;1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea;Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide
7 prices
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Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
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  • 1mg
  • 5mg
  • 10mg
  • ManufacturerAK Scientific
  • Product number5393CH
  • Product descriptionThyroidHormoneReceptorAntagonist,1-850
  • Packaging5mg
  • Price$294
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number5393CH
  • Product descriptionThyroidHormoneReceptorAntagonist,1-850
  • Packaging10mg
  • Price$464
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3006
  • Product descriptionThyroidHormoneReceptorAntagonist(1-850)
  • Packaging5mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3006
  • Product descriptionThyroidHormoneReceptorAntagonist(1-850)
  • Packaging10mg
  • Price$374
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17248
  • Product descriptionThyroid Hormone Receptor Antagonist (1-850) ≥98%
  • Packaging1mg
  • Price$45
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17248
  • Product descriptionThyroid Hormone Receptor Antagonist (1-850) ≥98%
  • Packaging5mg
  • Price$177
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17248
  • Product descriptionThyroid Hormone Receptor Antagonist (1-850) ≥98%
  • Packaging10mg
  • Price$330
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5393CH ThyroidHormoneReceptorAntagonist,1-850 5mg $294 2021-12-16 Buy
AK Scientific 5393CH ThyroidHormoneReceptorAntagonist,1-850 10mg $464 2021-12-16 Buy
ApexBio Technology C3006 ThyroidHormoneReceptorAntagonist(1-850) 5mg $200 2021-12-16 Buy
ApexBio Technology C3006 ThyroidHormoneReceptorAntagonist(1-850) 10mg $374 2021-12-16 Buy
Cayman Chemical 17248 Thyroid Hormone Receptor Antagonist (1-850) ≥98% 1mg $45 2024-03-01 Buy
Cayman Chemical 17248 Thyroid Hormone Receptor Antagonist (1-850) ≥98% 5mg $177 2024-03-01 Buy
Cayman Chemical 17248 Thyroid Hormone Receptor Antagonist (1-850) ≥98% 10mg $330 2024-03-01 Buy

Properties

Density :1.464±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤0.5mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
form :crystalline solid
pka :9.75±0.43(Predicted)
color :yellow

Safety Information

Symbol(GHS):
Signal word:
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Description

The activity of the thyroid hormones, L-thyroxine (T4; ) and 3,3',5-triiodo-L-thyronine (T3; ), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary. Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 μM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.