THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
- CAS No.
- 251310-57-3
- Chemical Name:
- THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
- Synonyms
- TR ANTAGONIST 1-850;THYROID HORMONE RECEPTOR ANTAGONIST, 1-850;1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea;2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE;Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide
- CBNumber:
- CB8468369
- Molecular Formula:
- C21H20F3N5O4
- Molecular Weight:
- 463.41
- MDL Number:
- MFCD06411459
- MOL File:
- Mol file
THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17248 | Thyroid Hormone Receptor Antagonist (1-850) ≥98% | 251310-57-3 | 1mg | $45 | 2024-03-01 | Buy |
| Cayman Chemical | 17248 | Thyroid Hormone Receptor Antagonist (1-850) ≥98% | 251310-57-3 | 5mg | $177 | 2024-03-01 | Buy |
| Cayman Chemical | 17248 | Thyroid Hormone Receptor Antagonist (1-850) ≥98% | 251310-57-3 | 10mg | $330 | 2024-03-01 | Buy |
| ApexBio Technology | C3006 | ThyroidHormoneReceptorAntagonist(1-850) | 251310-57-3 | 10mg | $374 | 2021-12-16 | Buy |
| AK Scientific | 5393CH | ThyroidHormoneReceptorAntagonist,1-850 | 251310-57-3 | 10mg | $464 | 2021-12-16 | Buy |
THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Chemical Properties,Uses,Production
Description
The activity of the thyroid hormones, L-thyroxine (T4; ) and 3,3'',5-triiodo-L-thyronine (T3; ), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary. Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 μM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.
target
thyroid hormone receptor
IC 50
1.5 μm
References
[1] schapira m, raaka b m, das s, et al. discovery of diverse thyroid hormone receptor antagonists by high-throughput docking[j]. proceedings of the national academy of sciences of the united states of america, 2003, 100(12): 7354-7359.
THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Preparation Products And Raw materials
Raw materials
Preparation Products
THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
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| Shanghai Lingfei Pharmaceutical Technology Co., Ltd | 15618928656 15618928656 | 771909552@qq.com | China | 1265 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |