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ChemicalBook >> CAS DataBase List >> 17β-hydroxy Wortmannin

17β-hydroxy Wortmannin

17β-hydroxy Wortmannin price.
  • $59 - $969
  • Product name: 17β-hydroxy Wortmannin
  • CAS: 58053-83-1
  • MF: C23H26O8
  • MW: 430.45
  • EINECS:
  • MDL Number:MFCD00939536
  • Synonyms:17β-hydroxy Wortmannin Exclusive;XLJORQYAOTYVQS-OGCOKEDGSA-N;17.beta.-hydroxy Wortmannin;PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem;3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6(1H)-dione, 11-(acetyloxy)-6b,7,8,9,9a,10,11,11b-octahydro-9-hydroxy-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9S,9aS,11R,11bR)-;17β-hydroxy Wortmannin;17β-hydroxy Wortmannin Exclusive
7 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • Sigma-Aldrich
Package
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • ManufacturerAK Scientific
  • Product number1267AH
  • Product description17beta-Hydroxywortmannin
  • Packaging5mg
  • Price$596
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1267AH
  • Product description17beta-Hydroxywortmannin
  • Packaging10mg
  • Price$969
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13812
  • Product description17β-hydroxy Wortmannin ≥98%
  • Packaging500μg
  • Price$59
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13812
  • Product description17β-hydroxy Wortmannin ≥98%
  • Packaging1mg
  • Price$108
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13812
  • Product description17β-hydroxy Wortmannin ≥98%
  • Packaging5mg
  • Price$448
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13812
  • Product description17β-hydroxy Wortmannin ≥98%
  • Packaging10mg
  • Price$783
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number528119
  • Product descriptionPI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem
  • Packaging5mg
  • Price$294
  • Updated2023-01-07
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1267AH 17beta-Hydroxywortmannin 5mg $596 2021-12-16 Buy
AK Scientific 1267AH 17beta-Hydroxywortmannin 10mg $969 2021-12-16 Buy
Cayman Chemical 13812 17β-hydroxy Wortmannin ≥98% 500μg $59 2024-03-01 Buy
Cayman Chemical 13812 17β-hydroxy Wortmannin ≥98% 1mg $108 2024-03-01 Buy
Cayman Chemical 13812 17β-hydroxy Wortmannin ≥98% 5mg $448 2024-03-01 Buy
Cayman Chemical 13812 17β-hydroxy Wortmannin ≥98% 10mg $783 2024-03-01 Buy
Sigma-Aldrich 528119 PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem 5mg $294 2023-01-07 Buy

Properties

Boiling point :615.4±55.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 0.15 mg/ml
form :Off-white solid
pka :14.49±0.70(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.