| Identification | Back Directory | [Name]
17β-hydroxy Wortmannin | [CAS]
58053-83-1 | [Synonyms]
17β-hydroxy Wortmannin
XLJORQYAOTYVQS-OGCOKEDGSA-N
17.beta.-hydroxy Wortmannin
17β-hydroxy Wortmannin Exclusive
17β-hydroxy Wortmannin Exclusive
PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem
3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6(1H)-dione, 11-(acetyloxy)-6b,7,8,9,9a,10,11,11b-octahydro-9-hydroxy-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9S,9aS,11R,11bR)- | [Molecular Formula]
C23H26O8 | [MDL Number]
MFCD00939536 | [MOL File]
58053-83-1.mol | [Molecular Weight]
430.45 |
| Chemical Properties | Back Directory | [Boiling point ]
615.4±55.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 0.15 mg/ml | [form ]
Off-white solid | [pka]
14.49±0.70(Predicted) | [color ]
off-white |
| Hazard Information | Back Directory | [Description]
17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin. |
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