1-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID synthesis

7synthesis methods

Product Name:1-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID
CAS Number:58386-33-7
Molecular formula:C15H11NO2
Molecular Weight:237.25

1H-Indole-2-carboxylicacid, 1-phenyl-, ethyl ester

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58386-33-7
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Yield:58386-33-7 96%

Reaction Conditions:

with sodium hydroxide in ethanol at 50; for 3 h;

Steps:

6.2 Preparation of 1-phenyl-1H-indole-2-carboxylic acid

49 mg (0.18 mmol) of the compound prepared in the above step 1 was dissolved in 4 ml of ethanol, 2N sodium hydroxide was added, and the mixture was stirred at 50 ° C for 3 hours.After completion of the reaction, the reaction mixture was extracted with ethyl acetate, washed with 4N hydrochloric acid solution and water, And dried over anhydrous sodium sulfate.And concentrated under reduced pressure to obtain 41 mg (0.17 mmol) of the desired compound as a white solid in 96% yield.

References:

KR101725451,2017,B1 Location in patent:Paragraph 0353; 0360-0362

108-86-1 Synthesis