Neratinib suppliers
Neratinib
- CAS:
- 698387-09-6
- MF:
- C30H29ClN6O3
- MW:
- 557.04
Suppliers by country/region
Company Type
Properties
- Melting point:
- 185-187°C
- Boiling point:
- 757.0±60.0 °C(Predicted)
- Density
- 1.33
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
- form
- Off-white solid.
- pka
- 12.37±0.43(Predicted)
- color
- Pale Yellow to Yellow
Safety Information
- Symbol(GHS)
GHS05
- Signal word
- Danger
- Hazard statements
- H314-H290
- Precautionary statements
- P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
- HS Code
- 29334900
Use
Neratinib developed by US Wyeth company is an irreversible epidermal growth factor receptor(EGFR) inhibitor. It is a multiple target point of small molecule tyrosine kinase inhibitors to HER 2 and HER1 after Lapatinib, and is an irreversible ErbB receptor tyrosine kinase inhibitor. Neratinib could selectively inhibit HER-1 and HER-2 of EGFR family(IC50 was 92 nmol/L and 59 nmol/L, respectively). Clinical research showed that Neratinib exerted significant therapeutic effect on non-small cell lung cancer, colon cancer, and breast cancer. The phaseⅡclinical trial indicated that Neratinib showed good efficacy and tolerance to HER-2 positive patients with advanced breast cancer who had been received or not Trastuzumab treatment. The phase Ⅲ breast cancer clinical trial was complete in September 2014. The data indicated that the efficacy of Neratinib was better than Roche's Herceptin in treatment of HER-2 positive early breast cancer. The above information is edited by the Chemicalbook of Liu Yujie.
250 supplier list of "Neratinib"
$0.00/ 1g
- Product Name:Neratinib (HKI-272)
- Products Intro:Purity: 98% HPLC | Package: 1g
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Inosine pranobex,Probenecid,Sodium Ceftiofur,3-O-Ethyl-L-ascorbic acid,benzhexol hydrochloride
- Product Name:Neratinib(HKI-272)
- Products Intro:Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:Neratinib
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Neratinib
- Products Intro:Purity: 0.99 | Package: 5KG;1KG | CustNote: Have any requirements, pls contact sales@zetchem.com
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceutical, agrochemical, speciality chemical and liquid crystal industries.
- Product Name:Neratinib
- Products Intro:Purity: >98% | Package: 500 mg | CustNote: Reach out to us for more information about custom solutions.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Neratinib
- Products Intro:Purity: 97% | Package: 5g;10g;25g
- Company Type: Trader
- Country/Region: CHINA
- Product Name:neratinib
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Neratinib
- Products Intro:Purity: 98% | Package: Package as requetsed
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Specialty chemical,UV Curing & Brightener,OLED Chemicals,CDMO SERVICES
- Product Name:Neratinib
- Products Intro:Purity: 99% | Package: 100g，1kg，10kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: drug intermediates,organic photoeletric materials,hybrid compounds,pharmaceuticals