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3-??????

3-??????
3-?????? ??? ???
?? ??:
1619-34-7
???:
3-??????
???(??):
3-??????
???:
3-Quinuclidinol
???(??):
QUINUCLIDIN-3-OL;Quinuclidinol;3-HYDROXYQUINUCLIDINE;Quinuclidine-3-ol;BENC-002;NSC 93905;Quinuclidinol-3;3-QUINUCLIDINOL;3-Quinuclidonol;3-HydroxyquinucL
CBNumber:
CB9694138
???:
C7H13NO
??? ??:
127.18
MOL ??:
1619-34-7.mol

3-?????? ??

???
220-223 °C(lit.)
?? ?
235.98°C (rough estimate)
??
1.0083 (rough estimate)
???
1.4790 (estimate)
?? ??
2-8°C
???
Aqueous Acidic (Slightly), Chloroform (Sparingly), Methanol (Slightly)
?? ?? (pKa)
14.75±0.20(Predicted)
??? ??
??? ??
??
???? ????
???
??
??
Air Sensitive
Merck
14,8082
BRN
104327
LogP
0.17
CAS ??????
1619-34-7(CAS DataBase Reference)
NIST
3-Quinuclidinol(1619-34-7)
EPA
1-Azabicyclo[2.2.2]octan-3-ol (1619-34-7)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? C,F
?? ???? ?? 34-11
????? 26-36/37/39-45-16
????(UN No.) UN 3263 8/PG 2
WGK ?? 3
RTECS ?? VD6191700
F ?????? 34
?? ?? ?? Corrosive
TSCA Yes
?? ?? 8
???? III
HS ?? 29333920
?? ?? ??? 1619-34-7(Hazardous Substances Data)
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H314 ??? ?? ??? ?? ??? ??? ????? ?? ????? ?? 1A, B, C ?? GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
??????:
P260 ??·?·??·???·??·...·????? ???? ???.
P280 ????/???/???/?????? ?????.
P303+P361+P353 ??(?? ????)? ??? ??? ?? ??? ??? ????? ??? ?? ????/?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P363 ?? ??? ??? ??? ?????.
NFPA 704
1
3 0

3-?????? MSDS


3-Quinuclidinol

3-?????? C??? ??, ??, ??

??? ??

Crystalline Solid

??

3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction.

??

ChEBI: Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group.

???

Mutation.

3-?????? ?? ?? ? ???

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3-?????? ?? ??:

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