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EED226

EED226 ??? ???
?? ??:
2083627-02-3
???:
EED226
???(??):
EED226;CS-2549;EED226;EED 226;EED226, 10 mM in DMSO;EED226;EED 226;MAK683;MAK683(EED226/Compound 43);N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine;1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-(2-furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-;N-[(furan-2-yl)methyl]-8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
CBNumber:
CB93164715
???:
C17H15N5O3S
??? ??:
369.4
MOL ??:
2083627-02-3.mol

EED226 ??

??
1.49±0.1 g/cm3(Predicted)
?? ??
-20°
???
DMSO? ?????(?? 25mg/ml).
?? ?? (pKa)
1.19±0.30(Predicted)
??? ??
??
??? ??
??? ??
??
???
???
??? ?? ?????? 1? ?? ??????. DMSO? ???? ?? 1?? ?? -20°?? ??? ? ????.
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2B ?? P264, P305+P351+P338,P337+P313
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
2 0

EED226 C??? ??, ??, ??

??

EED 226 is a potent, selective and orally bioavailable EED inhibitor, inducing robust and sustained tumor regression in specific models. Effective PRC2 inhibitorin the treatment of PRC2-dependant cancers.

EED226 ?? ?? ? ???

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?? ??

EED226 ?? ??

???( 86)?? ??
??? ?? ??? ?? ?? ? ??
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EED226 ?? ??:

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