GSK-2126458
|
|
GSK-2126458 ??
- ???
- 187-189℃
- ?? ?
- 715.6±70.0 °C(Predicted)
- ??
- 1.45
- ?? ??
- Refrigerator
- ???
- ????? (?? ???), DMSO (?? ???), ???(?? ??, ??)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 6.23±0.40(Predicted)
- ??
- ???? ?? ???
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| HS ?? | 29350090 |
|---|
GSK-2126458 C??? ??, ??, ??
??
GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.??
A highly potent inhibitor of PI3K and the mammalian target of Rapamycin.GSK-2126458 ?? ?? ? ???
???
?? ??
GSK-2126458 ?? ??
???( 181)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29730 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29856 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49732 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32268 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 22866 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 |
shawn@hirisunpharm.com | CHINA | 9911 | 58 |
GSK-2126458 ?? ??:
??? ????
AZD-8055
MK-2206 2HCl
Pictilisib
Erlotinib hydrochloride
Danirixin
daprodustat,GSK1278863
GSK1940029
GSK 189254A
GSK2110183
gsk2200150a
4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
AZD-3965
GSK1292263
7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine
GSK-3beta Inhibitor XXVI(GSK-3b)
LY 294002 Hydrochloride