ChEBI: The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularl
that associated with irritable bowel syndrome.
World Health Organization (WHO)
Dicycloverine, an anticholinergic agent with antispasmodic and
local anaesthetic activity, was introduced in 1952 for treatment of functional
conditions involving smooth muscle of the gastrointestinal tract. Its use in the
treatment of colic in infants under six months of age has been associated with
irritability and restlessness, convulsions and apnoea which has led the major
manufacturer to issue revised global prescribing information in 1985
contraindicating the use of dicycloverine in this age group. Subsequently
restrictive regulatory action directed to other available brands of this drug was taken in several countries. Preparations containing dicycloverine remain available
in at least ten major markets.
