ChemicalBook >?? ???? >API>?? ? ?? ?>? ??? (anti-tuberculous mycobacterium leprae drugs)>2-???? ??????
2-???? ??????
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2-???? ?????? ??
- ???
- 300-304 °C (lit.)
- ?? ?
- 270.6±23.0 °C(Predicted)
- ??
- 1.42
- ???
- 0-0.001Pa at 25℃
- ???
- 1.5500 (estimate)
- ???
- >250°C
- ?? ??
- 2-8°C
- ???
- 0.3g/L
- ??? ??
- ??
- ?? ?? (pKa)
- 10.24±0.10(Predicted)
- ??
- ???? ????
- ???
- 23.5&C?? <0.1g/100mL
- Merck
- 14,1082
- BRN
- 119867
- ???
- ????. ?? ???? ???? ????.
- LogP
- 0.88-1.66 at 20-25℃
- CAS ??????
- 583-39-1(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
??? ?? | Xn | ||
---|---|---|---|
?? ???? ?? | 20/21/22-36/37/38-22 | ||
????? | 26-36-24/25 | ||
????(UN No.) | UN 2811 6.1/PG 3 | ||
WGK ?? | 2 | ||
RTECS ?? | DE1050000 | ||
?? ?? ?? | 480 °C | ||
TSCA | Yes | ||
?? ?? | 6.1 | ||
???? | III | ||
HS ?? | 29339910 | ||
?? | LD50 orally in Rabbit: 300 mg/kg | ||
???? ?? | KE-10607 |
2-???? ?????? C??? ??, ??, ??
??? ??
yellow or white crystals??
2-Mercaptobenzimidazole is used as an antidegradant. It is utilized for protecting rubber from oxidation. It is also employed as an intermediate in the preparation of rabeprazole. Further, it finds application in anti-leprosy drugs in medicine. In addition to this, it is used as a copper plating brightener.?? ??
White to yellow crystals or cream colored powder. Slight odor.??? ?? ??
Dust explosion: 0.140 oz/ft3. Insoluble in water. 2-Mercaptobenzimidazole is moisture sensitive. .?? ???
An organosulfide and an amine. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.????
Flash point data for 2-Mercaptobenzimidazole are not available; however, 2-Mercaptobenzimidazole is probably combustible.Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Skin and eye irritant. When heated to decomposition it emits toxic fumes of SO, and NO,. See also MERCAPTANS.Purification Methods
Crystallise it from aqueous EtOH, AcOH or aqueous ammonia. It complexes with many metals. [Brown J Chem Soc 1976 1958, Beilstein 24 II 65, 24 III/IV 287.]2-???? ?????? ?? ?? ? ???
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2-???? ?????? ?? ??
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