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ADIPORON

ADIPORON ??? ???
?? ??:
924416-43-3
???:
ADIPORON
???(??):
CS-918;104890;AdipiRon;AdipoRon;SC-396658;AdipoR agonist;AdipoRon (SC-396658);924416-43-3, CFCD924416433,;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide;2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide
CBNumber:
CB82681793
???:
C27H28N2O3
??? ??:
428.52
MOL ??:
924416-43-3.mol
MSDS ??:
SDS

ADIPORON ??

???
106-108°C
?? ?
645.3±55.0 °C(Predicted)
??
1.21±0.1 g/cm3(Predicted)
?? ??
room temp
???
DMSO: ???10mg/mL, ??
?? ?? (pKa)
13.92±0.20(Predicted)
??? ??
??
??
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??? ?? ?????? 1? ?? ??????. DMSO ?? ??? ??? -20°?? ?? 2?? ?? ??? ? ????.
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn,N
?? ???? ?? 22-50/53
????? 60-61
????(UN No.) UN 3077 9 / PGIII
WGK ?? 3
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H410 ??? ??? ?? ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
??????:
P273 ???? ???? ???.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

ADIPORON C??? ??, ??, ??

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Adiponectin expressed by adipocytes exerts antidiabetic effects by binding to adiponectin receptor (AdipoR)1, which activates AMPK pathways, and AdipoR2, which activates PPARα pathways. AdipoRon is an orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 with KD values of 1.8 and 3.1 μM, respectively. At 50 mg/kg, it acts similarly to adiponectin, activating AMPK and PPARα pathways and reducing insulin resistance and glucose intolerance in wild type mice fed a high-fat diet and in genetically obese db/db mice.

Biochem/physiol Actions

AdipoRon is an adiponectin agonist that binds to and activates adiponectin receptors AdipoR1 and AdipoR2, activating AMPK and PPAR-α pathways, and ameliorating insulin resistance and glucose intolerance in mice fed a high-fat diet in a manner similar to adiponectin itself. AdipoRon did not affect body weight, but did increase the expression of genes involved in fatty-acid oxidation, decreased tissue triglyceride content, and prolonged the shortened lifespan of db/db mice.

ADIPORON ?? ?? ? ???

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