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1-Boc-Azetidine-3-yl-methanol

1-Boc-Azetidine-3-yl-methanol ??? ???
?? ??:
142253-56-3
???:
1-Boc-Azetidine-3-yl-methanol
???(??):
TERT-BUTYL 3-(HYDROXYMETHYL)AZETIDINE-1-CARBOXYLATE;EOS-61767;Boc-Azetidin-3-ylMethanol;1-Boc-3-(hydroxymethyl)az...;1-BOC-AZETIDINE-3-YL METHANOL;1-Boc-3-azetidinemethanol,95%;1-Boc-3-azetidineMethanol, 95%;1-N-Boc-3-hydroxyMethyazetidine;1-Boc-3-(hydroxymethyl)azetidine;1-Boc-3-(hydroxyMethyl)azetidine, 97+%
CBNumber:
CB8246260
???:
C9H17NO3
??? ??:
187.24
MOL ??:
142253-56-3.mol

1-Boc-Azetidine-3-yl-methanol ??

???
55 °C
?? ?
268-273℃
??
1.115
???
117°(243°F)
?? ??
2-8°C
???
????????(DMSO)? ?????.
?? ?? (pKa)
14.82±0.10(Predicted)
??? ??
powder to lump
??
???? ?? ??
InChI
InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-4-7(5-10)6-11/h7,11H,4-6H2,1-3H3
InChIKey
HXRDRJKAEYHOBB-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC(CO)C1
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 23-26-37-60
TSCA No
?? ?? IRRITANT
HS ?? 29339900
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405 ???? ?????.
NFPA 704
1
2 0

1-Boc-Azetidine-3-yl-methanol C??? ??, ??, ??

??

1-Boc-Azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). This compound is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

??? ??

Clear colorless liquid

??

It is an intermediate in organic syntheses

1-Boc-Azetidine-3-yl-methanol ?? ?? ? ???

???

??????? ??? ? -Tert- ?? ? ????? ???? ???? N,N-???????????? ??? ????? ??? ???????? ????????? ???????? ??? ??? ????? ?? ?????? ???? ?????? ??? ??? ?? ??? ????(??)

?? ??

1-Boc-Azetidine-3-yl-methanol ?? ??

???( 279)?? ??
??? ?? ??? ?? ?? ? ??
Shanghai Boc Chemical Co., Ltd.
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1-Boc-Azetidine-3-yl-methanol ?? ??:

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