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FGIN-1-27

FGIN-1-27 ??? ???
?? ??:
142720-24-9
???:
FGIN-1-27
???(??):
FGIN-1-27;FGIN-1-27,98%;FGIN-1-27, 10 mM in DMSO;N,N-DIHEXYL-2-(4-FLUOROPHENYL)INDOLE-3-ACETAMIDE;N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide;1H-Indole-3-acetamide, 2-(4-fluorophenyl)-N,N-dihexyl-;FGIN-1-27N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide;2-(2-(4-Fluorophenyl)-1H-indol-3-yl)-N,N-dihexylacetamide;indoleacetamide,Inhibitor,inhibit,BBB,FGIN127,blood brain barrier,FGIN 1 27,FGIN 1-27,peripheral benzodiazepine receptor,convulsions,Isoniazid,PBR
CBNumber:
CB8157605
???:
C28H37FN2O
??? ??:
436.6
MOL ??:
142720-24-9.mol
MSDS ??:
SDS

FGIN-1-27 ??

???
96-97 °C
?? ?
608.3±55.0 °C(Predicted)
??
1.0538 (estimate)
?? ??
2-8°C
???
???: 20mg/mL
??? ??
?? ??.
?? ?? (pKa)
16.45±0.30(Predicted)
??
Off-white to light yellow

??

????? 24/25
WGK ?? 3
HS ?? 29339980

FGIN-1-27 C??? ??, ??, ??

??? ??

white to off-white powder

??

FGIN-1-27 is a potent inositol monophosphatase inhibitor.

???? ??

Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC 50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.

FGIN-1-27 ?? ?? ? ???

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FGIN-1-27 ?? ??

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