?????
|
|
????? ??
- ???
- 142℃
- ?? ?
- 440.55°C (rough estimate)
- ??
- 1.1150 (rough estimate)
- ???
- 1.7620 (estimate)
- ?? ??
- Sealed in dry,Room Temperature
- ???
- DMSO? ???
- ??? ??
- ??
- ?? ?? (pKa)
- 6.55±0.22(Predicted)
- ??
- ???? ?????
- Merck
- 14,1213
- LogP
- 4.770
- CAS ??????
- 60628-96-8(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
????? C??? ??, ??, ??
??
Bifonazole represents the first topical broad spectrum antimycotic approved for once daily administration. Its in vitro activity appears equivalent to its structural relative clotrimazole, being effective against dermatophytes, other filamentous fungi, dimorphic fungi and yeasts.??? ??
White or almost white, crystalline powder.??
Bifonazole is an imidazole antifungal agent and calmodulin antagonist. It causes a reduction in glycolysis and ATP levels in B16 melanoma cells. Bifonazole is an inhibitor of C14orf1. Bifonazole is an imidazole-based anti-fungal agent with broad spectrum activity against many fungi, molds, yeast and some gram-positive bacteria. Bifonazole inhibits ergosterol biosynthetic protein 28 and Cytochrome P450 2B4.????? ?? ?? ? ???
???
???
2,2'-Bis(2-chlorophenyl)-4,4',5,5'-tetraphenyl-1,2'-biimidazole
?? ???
????
??? ?????
4-???????
??-??[1,1'-???]-4-???
4-(???????)-1,1'-???
4-??????
4-BENZYLANILINE
????????
?? ??
????? ?? ??
???( 470)?? ??
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