3-Nitrophthalic anhydride
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3-Nitrophthalic anhydride ??
- ???
- 163-165 °C (lit.)
- ?? ?
- 329.3°C (rough estimate)
- ??
- 1.6392 (rough estimate)
- ???
- 1.4700 (estimate)
- ?? ??
- Store below +30°C.
- ??? ??
- ??? ??
- ??
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- Moisture Sensitive
- BRN
- 179963
- CAS ??????
- 641-70-3(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36-37/39 | ||
| WGK ?? | 3 | ||
| F ?????? | 10-21 | ||
| TSCA | Yes | ||
| HS ?? | 29173980 |
3-Nitrophthalic anhydride C??? ??, ??, ??
??? ??
Beige to yellow crystalline powder??
An intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472). Reactions with aminoquinazolinones yield phthalimidoquinazolinones.?? ??
3-Nitrophthalic anhydride can be prepared by heating 3-nitrophthalic acid under various conditions and by the action of acetic anhydride, essentially as in the procedure described. The direct nitration of phthalic anhydride yields 3-nitrophthalic anhydride together with the isomeric 4-nitro compound.Purification Methods
Crystallise it from *C6H6, *C6H6/pet ether, Me2CO, AcOH, or Ac2O (m 164-165o). Dry it at 100o. [Beilstein 17 III/IV 6149, 17/11 V 266.]3-Nitrophthalic anhydride ?? ?? ? ???
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3-Nitrophthalic anhydride ?? ??
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