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??-EAPII(TTRAP)

??-EAPII(TTRAP)
??-EAPII(TTRAP) ??? ???
?? ??:
828934-41-4
???:
??-EAPII(TTRAP)
???(??):
??-EAPII(TTRAP)
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(R)-(+)-Etomoxir sodium salt
???(??):
CS-119;ANTI-EAPII;(+)-Etomoxir;Etomoxir(Nasalt);(R)-(+)-Etomoxir Na;(+)-Etomoxir sodium;Etomoxir hydrate sodium;(R)-(+)-Etomoxir Sodium;(+)-Etomoxir sodium salt;(+)-etomoxir sodium hydrate
CBNumber:
CB7972308
???:
C15H20ClNaO4
??? ??:
322.76
MOL ??:
828934-41-4.mol
MSDS ??:
SDS

??-EAPII(TTRAP) ??

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Inert atmosphere,2-8°C
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H2O: ???? ???
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??? ?? ?????? 1? ?? ??????. DMSO? ???? -20°C?? ?? 1?? ?? ??? ? ????.
InChI
InChI=1/C15H19ClO4.Na.H/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;/t15-;;/s3
InChIKey
WENJLJJSJDAJDN-QCUBGVIVSA-M
SMILES
C([C@]1(OC1)C(=O)O)CCCCCOC1C=CC(Cl)=CC=1.[NaH] |&1:1,r|
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 22
????(UN No.) UN 2811 6.1/PG 3
WGK ?? 3
HS ?? 2918999090
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
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P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

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(+)-Etomoxir sodium salt hydrate has been used as an inhibitor of carnitine palmitoyltransferase 1 (CPT-1) in breast tumor cell lines and mice tumor. It has also been used as an inhibitor of fatty acid oxidation in human primary prostate epithelial cells and lymphocytes.

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Mix raw material A with solvent (tetrahydrofuran), then add catalyst, heat to a certain temperature, add p-chlorophenol, nitrogen, stirring reaction, the reaction solution is dry, remove the solvent, the resulting solid is re-dispersed in anhydrous ethanol, add sodium hydroxide solution, stirring to 30-50 ° C reaction, after the reaction is concentrated under reduced pressure, concentrate is dried, the product is produced.

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(+)-Etomoxir sodium salt hydrate belongs to oxirane carboxylic acid group of compounds and mediates metabolic channeling of fatty acid precursors. It favors oxidative stress in T cells and prevents T cell differentiation. It inhibits fatty acid oxidation and promotes hunger and food intake. Etomoxir impairs myeloid-derived suppressor cells mediated tumor and could have potential therapeutic potential.

Biochem/physiol Actions

Irreversible O-carnitine palmitoyltransferase-1 (CPT-1) inhibitor; PPARα activator

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