ChemicalBook >?? ???? >??-EAPII(TTRAP)
??-EAPII(TTRAP)
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??-EAPII(TTRAP) ??
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- Inert atmosphere,2-8°C
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- H2O: ???? ???
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- ??? ?? ?????? 1? ?? ??????. DMSO? ???? -20°C?? ?? 1?? ?? ??? ? ????.
- InChI
- InChI=1/C15H19ClO4.Na.H/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;/t15-;;/s3
- InChIKey
- WENJLJJSJDAJDN-QCUBGVIVSA-M
- SMILES
- C([C@]1(OC1)C(=O)O)CCCCCOC1C=CC(Cl)=CC=1.[NaH] |&1:1,r|
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(+)-Etomoxir sodium salt hydrate has been used as an inhibitor of carnitine palmitoyltransferase 1 (CPT-1) in breast tumor cell lines and mice tumor. It has also been used as an inhibitor of fatty acid oxidation in human primary prostate epithelial cells and lymphocytes.?? ??
Mix raw material A with solvent (tetrahydrofuran), then add catalyst, heat to a certain temperature, add p-chlorophenol, nitrogen, stirring reaction, the reaction solution is dry, remove the solvent, the resulting solid is re-dispersed in anhydrous ethanol, add sodium hydroxide solution, stirring to 30-50 ° C reaction, after the reaction is concentrated under reduced pressure, concentrate is dried, the product is produced.?? ??
(+)-Etomoxir sodium salt hydrate belongs to oxirane carboxylic acid group of compounds and mediates metabolic channeling of fatty acid precursors. It favors oxidative stress in T cells and prevents T cell differentiation. It inhibits fatty acid oxidation and promotes hunger and food intake. Etomoxir impairs myeloid-derived suppressor cells mediated tumor and could have potential therapeutic potential.Biochem/physiol Actions
Irreversible O-carnitine palmitoyltransferase-1 (CPT-1) inhibitor; PPARα activator??-EAPII(TTRAP) ?? ?? ? ???
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??-EAPII(TTRAP) ?? ??
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??-EAPII(TTRAP) ?? ??:
????? ??(2,2,6,6-?????-3,5-???????) ?? ????????? ??????? ?2? ???(II) ????????? ?????? ??????? ?? ???? ?????????
R-(+)-ETOMOXIR
SALCOMINE
Tosylmethyl isocyanide
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
PHENYLSELENOL
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
Ethyl isocyanoacetate
Benzyl isocyanide
METHYL ISOCYANOACETATE
Tris(2,4-pentanedionato)chroMiuM(III)
TERT-BUTYL ISOCYANIDE