ChemicalBook >?? ???? >Pomalidomide-PEG4-azide
Pomalidomide-PEG4-azide
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Pomalidomide-PEG4-azide ??
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- 2-8°C
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- Oil
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- Light yellow to green yellow
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Pomalidomide-PEG4-azide C??? ??, ??, ??
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Protein degrader builiding block Pomalidomide-PEG4-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Pomalidomide-PEG4-azide ?? ?? ? ???
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Pomalidomide-PEG4-azide ?? ??
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
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Aladdin Scientific | +1-+1(833)-552-7181 |
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Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18021050169 |
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Sigma-Aldrich | 021-61415566 800-8193336 |
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Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 |
psaitong@jm-bio.com | China | 12306 | 58 |
Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 |
1924344760@qq.com | China | 4825 | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 |
1927928688@qq.com | China | 1467 | 58 |
Pomalidomide-PEG4-azide ?? ??:
Pomalidomide-PEG2-N3
Pomalidomide-PEG2-butyl iodide
E3 Ligase Ligand-Linker Conjugates 22
4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Pomalidomide-PEG4-CO2H
E3 Ligase Ligand-Linker Conjugates 1
POMALIDOMIDE-PEG2-CO2H
Pomalidomide-PEG1-azide
Pomalidomide-PEG5-CO2H
POMALIDOMIDE-PEG1-CO2H
Pomalidomide-O-C4-NH2
Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
Pomalidomide-PEG3-N3
Pomalidomide-PEG6-butyl iodide
Pomalidomide-NH-PEG2-azide
Pomalidomide-NH-PEG6-azide
Pomalidomide-NH-PEG1-azide
Pomalidomide-NH-PEG5-azide