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Triprolidine

Triprolidine ??? ???
?? ??:
486-12-4
???:
Triprolidine
???(??):
Triprolidin;NCI-C61450;(e)-pyridin;TRIPROLIDINE;Tripyrolidine;Triprolidine USP/EP/BP;(E)-1-(2-pyridyl)-3-pyrrolidin-1-yl-1-p-tolylpropene;trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene;trans-2-[3-(1-Pyrrolidinyl)-1-p-tolypropenyl]pyridine;(E)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine
CBNumber:
CB7782853
???:
C19H22N2
??? ??:
278.39
MOL ??:
486-12-4.mol

Triprolidine ??

???
59-61°
?? ?
435.4±34.0 °C(Predicted)
??
1.061±0.06 g/cm3(Predicted)
?? ?? (pKa)
pKa 4.01(H2O t = 23.0) (Uncertain);9.69(H2O t = 23.0) (Uncertain)
CAS ??????
486-12-4(CAS DataBase Reference)
NIST
Triprolidine(486-12-4)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

Triprolidine C??? ??, ??, ??

??

Antihistaminic.

??

ChEBI: An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms o uticaria, rhinitis, and various pruritic skin disorders.

Triprolidine ?? ?? ? ???

???

???? Lithium p-??????? Para-??????? 2-??????

?? ??

Triprolidine ?? ??

???( 52)?? ??
??? ?? ??? ?? ?? ? ??
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Triprolidine ?? ??:

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