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CHPG

CHPG ??? ???
?? ??:
170846-74-9
???:
CHPG
???(??):
CHPG;(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE;α-amino-2-chloro-5-hydroxybenzeneacetic acid;Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-;(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid;α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine
CBNumber:
CB7723281
???:
C8H8ClNO3
??? ??:
201.61
MOL ??:
170846-74-9.mol

CHPG ??

?? ?
407.3±45.0 °C(Predicted)
??
1.531±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
DMSO: ≥10mg/mL
??? ??
?? &_& ?? ??
?? ?? (pKa)
1.61±0.10(Predicted)
??
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
2 0

CHPG C??? ??, ??, ??

??

(R,S)-CHPG is a potent and selective agonist at metabotropic glutamate receptor 5 (mGluR5). In CHO cells, it had an EC50 of 750 μM for calcium mobilization in mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells. In transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (Kis = 0.9 and 3.9 μM, respectively) but not ionotropic glutamate receptors. It reduced oxidative stress and inflammatory markers in cultured BV-2 microglial cells. In mouse models of traumatic brain injury, it reduced lesion volume, improved sensorimotor deficits in the beam walk test, and improved spatial memory in the Morris water maze.

??

CHPG is a selective mGluR-5 agonist.

???? ??

A selective mGlu 5 metabotropic glutamate receptor agonist, completely inactive at mGlu 1a receptors expressed in CHO cells. Active in vivo .

CHPG ?? ?? ? ???

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CHPG ?? ??

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