ChemicalBook >?? ???? >Adaptaquin
Adaptaquin
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Adaptaquin ??
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- 650.9±55.0 °C(Predicted)
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- 1.437±0.06 g/cm3(Predicted)
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- -20C
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- ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide
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- ?? ?? (pKa)
- 4.07±0.50(Predicted)
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- White to yellow
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Adaptaquin C??? ??, ??, ??
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This brain-penetrant PHD2 inhibitor and antioxidant (FW = 377.82 g/mol; CAS 385786-48-1; Soluble to 100 mM in DMSO), also named 7-[(4chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol, targets Hypoxia-Inducible Factor (or HIF) prolyl hydroxylase-2, a critical regulator of hematopoietic stem cell (HSC) maintenance during steadystate and stress. Indeed, this branched oxyquinoline molecule was named adaptaquin (AQ) to signify its ability to inhibit the HIF-PHDs and activate adaptive responses to hypoxia. Hypoxia is a prominent feature in the maintenance of HSC quiescence and multipotency. Adaptaquin also exhibits neuroprotective effects, enhancing functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes.Adaptaquin ?? ?? ? ???
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Adaptaquin ?? ??
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| ??? | ?? | ??? | ?? | ?? ? | ?? |
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| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
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| Aladdin Scientific | +1-+1(833)-552-7181 |
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| BOC Sciences | 1-631-485-4226; 16314854226 |
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| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 |
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| DC Chemicals | 021-58447131 13564518121 |
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| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
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| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 |
3477467573@qq.com | China | 8617 | 58 |