??????????
|
|
?????????? ??
- ???
- -28 °C
- ?? ?
- 146-148 °C/750 mmHg (lit.)
- ??
- 2.007 g/mL at 25 °C (lit.)
- ???
- 1.485-1.495
- ???
- 4°C
- ???
- Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly), Methanol (Slig
- ?? ?? (pKa)
- 7.22±0.29(Predicted)
- ??? ??
- ??
- ??
- ?? ???
- ???
- ???, ???
- CAS ??????
- 563-70-2(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn-O,Xi,O | ||
|---|---|---|---|
| ?? ???? ?? | 8-36/37/38-20/21/22 | ||
| ????? | 36/37/39-26-17-36 | ||
| ????(UN No.) | 3098 | ||
| WGK ?? | 3 | ||
| RTECS ?? | PA5360000 | ||
| ?? ?? | 5.1 | ||
| ???? | III | ||
| HS ?? | 29049095 | ||
| ???? ?? | KE-03689 |
| ????(GHS): |
 
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| ?? ?: | Danger | |||||||||||||||||||||||||||||||||||
| ??·?? ??: |
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Bromonitromethane is a clear yellow liquid, It is a strong oxidizing agent with properties similar to nitromethane.Bromonitromethane has been used:
in production of various protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung amide synthesis.
in preparation of (Z)-1-bromo-1-nitroalkenes via sodium iodide-catalyzed Henry reaction.
in diastereo- and enantioselective cyclopropanation of β,γ-unsaturated a-ketoesters via domino Michael-addition/intramolecular-alkylation strategy.
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Bromonitromethane has received considerable attention as a one-carbon synthon for the synthesis of a variety of important organic intermediates.Bromonitromethane is a key starting material for the preparation of the broad-spectrum antibiotic trovafloxacin, which contains the interesting 3-azabicyclo[ 3.1.0]hexane ring system.
it was used in the synthesis of 2-nitrobenzofuran and 2-nitro-2,3-dihydrobenzofuran-3-ols, nitrobenzothio-phenes, and nitrothiazoles, polyfunctionalized nitrocyclopropanes. It has also been utilized in the synthesis of 1-bromo-1-nitroalkan-2-ols and aryl nitromethanes. In addition, it could be used as a bromine donor.
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Bromonitromethane is commercially available and can also be easily prepared according to the procedures reported by Fishwick et al. A typical procedure is as following: freshly distilled nitromethane was stirred at 0℃ and bromine was dropped in 5 seconds. The resulted bromonitromethane could be used without further purification.?????????? ?? ?? ? ???
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Bromophenol Red
Bromophenol Blue
Bromophenol blue aqueous solution
Bromothymol Blue
beta-Bromostyrene
2-Bromo-2-methylpropane
tribromonitromethane
nibroxane
5-Bromo-5-nitro-1,3-dioxane
Debropol
BROMOCHLORONITROMETHANE
2-Bromo-2-nitroethanol