ChemicalBook >?? ???? >??-1002
??-1002
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??-1002 ??
- ???
- 87 - 92°C
- ?? ?
- 506.5±35.0 °C(Predicted)
- ??
- 1.045±0.06 g/cm3(Predicted)
- ?? ??
- Refrigerator
- ???
- ?????(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 4.55±0.45(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ???? ?????
- InChI
- InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
- InChIKey
- HYHMLYSLQUKXKP-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
??-1002 C??? ??, ??, ??
??
Etc-1002 is a small molecule that can be used orally to lower LDL-C and is an activator of LIVER AMPK. ETC-1002 has an effective inhibitory effect on liver ATP-Citrate lyase.??
ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).???
NEXLETOL, NEXLIZET??-1002 ?? ?? ? ???
???
methyl 3-bromo-2,2-dimethylpropanoate
Hexanoic acid, 6-bromo-2,2-dimethyl-, methyl ester
Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-, 1,15-diethyl ester
2,2,14,14-tetramethyl-8-oxopentadecanedioic acid
2,2,14,14-?????-8-?????????????????
ethyl 6-bromo-2,2-dimethylhexanoate
1,5-??????
?? ??
??-1002 ?? ??
???( 266)?? ??
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