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GNE-9605

GNE-9605 ??? ???
?? ??:
1536200-31-3
???:
GNE-9605
???(??):
CS-1831;GNE-9605;GNE-9605 USP/EP/BP;GNE-9605;GNE9605;GNE 9605;Diazepam-d8 (exempt preparation);N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine;rel-N2-(5-Chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-
CBNumber:
CB72715631
???:
C17H20ClF4N7O
??? ??:
449.83
MOL ??:
1536200-31-3.mol

GNE-9605 ??

?? ?
587.9±60.0 °C(Predicted)
??
1.67±0.1 g/cm3(Predicted)
?? ??
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
???
≥22.5 mg/mL in DMSO
??? ??
??
??? ??
??? ??
?? ?? (pKa)
5.04±0.60(Predicted)
??
White to off-white
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H400 ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
H410 ??? ??? ?? ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P273 ???? ???? ???.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P330 ?? ?????.
P391 ???? ????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

GNE-9605 C??? ??, ??, ??

??

GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.

GNE-9605 ?? ?? ? ???

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GNE-9605 ?? ??

???( 75)?? ??
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ATK CHEMICAL COMPANY LIMITED
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sales@aceschem.com United States 19632 58

GNE-9605 ?? ??:

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