Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
???
≥22.5 mg/mL in DMSO
??? ??
??
??? ??
??? ??
?? ?? (pKa)
5.04±0.60(Predicted)
??
White to off-white
??
?? ? ?? ??
?? ? ???? ?? (GHS)
????(GHS):
?? ?:
Warning
??·?? ??:
??
??·?? ??
?? ??
??
?? ?
?? ??
P- ??
H302
??? ???
?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
H400
????? ?? ???
?? ????? ?? - ??
?? 1
??
P273, P391, P501
H410
??? ??? ?? ????? ?? ???
?? ????? ?? - ??
?? 1
??
P273, P391, P501
??????:
P264
?? ??? ?? ??? ????.
P264
?? ??? ?? ??? ????.
P270
? ??? ??? ??? ???, ???? ???? ???.
P273
???? ???? ???.
P301+P312
??? ???? ??? ????(??)? ??? ????.
P330
?? ?????.
P391
???? ????.
P501
...? ??? / ??? ?? ???.
NFPA 704
0
2
0
GNE-9605 C??? ??, ??, ??
??
GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.
