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MicafunginFR-179642???(?)

MicafunginFR-179642???(?) ??? ???

?? ??:: 168110-44-9

???:: MicafunginFR-179642???(?)

???(??):: MicafunginFR-179642???(?)

???:: Micafungin FR-179642 impurity (acid)

???(??):: FR-179642;Micafungin FR-179642;1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0;FRAN;MFA/CBR03-2;FR179642, CMICA;FR 179642 (~90%);Micafungin Nucleus;US-DMF No.: 030028;N-1 Micafungin Sodium

CBNumber:: CB72657658

???:: C35H52N8O20S

??? ??:: 936.89

MOL ??:: 168110-44-9.mol

?? ?? 173

MicafunginFR-179642???(?) ??

???: >150oC (dec.)

??: 1.75±0.1 g/cm3 (20 ºC 760 Torr)

?? ??: Hygroscopic, -20°C Freezer, Under inert atmosphere

???: DMSO(?? ??), ???(?? ??, ??? ??)? ???

?? ?? (pKa): -4.46±0.18(Predicted)

??? ??: ??

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?? ? ???? ?? (GHS)

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Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??
H412	??? ??? ?? ????? ???	?? ????? ?? - ??	?? 3		P273, P501

??????:

P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P273	???? ???? ???.
P280	????/???/???/?????? ?????.
P302+P352	??? ??? ??? ?? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321	(…) ??? ???.
P332+P313	?? ??? ??? ???? ??· ??? ????.
P362	??? ??? ?? ?? ?? ?????
P501	...? ??? / ??? ?? ???.

MicafunginFR-179642???(?) C??? ??, ??, ??

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FR 179642 is an impurity of Micafungin (M342350), a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species.

??

Micafungin FR-179642 impurity (acid) is an impurity in micafungin that can be present as trace amounts in the final product and may contribute to hemolytic activity. This impurity is formed by hydrolysis during the synthesis process. Micafungin is an antifungal drug that inhibits the synthesis of ergosterol, a vital component of fungal cell membranes.

MicafunginFR-179642???(?) ?? ?? ? ???

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MicafunginFR-179642???(?) ?? ??

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???	??	???	??	?? ?	??
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MicafunginFR-179642???(?) ?? ??:

Micafungin sodium Anidulafungin 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1) Micafungin FR901379 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid Micafungin Side Chain Methyl Ester Mirabegron Impurity 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine 2(RS)-4-Methyl-1-(3-Methylpyridin-2-yl)-2-phenylpiperazine Mirabegron Impurity 3 Mirtazapine N-Oxide 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine Merariveron impurity C Mirabegron Impurity 1-(3-Cyanopyridyl-2)-2-Phenyl-4-Methylpyperazine Mirabegron Impurity 31 Mirabegron Impurity 30

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