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?? ??:: 139272-67-6

???:: ????????????

???(??):: ????????????

???:: Aceclofenac Ethyl Ester

???(??):: Aceclofenac Ethyl Ester;Aceclofenac EP IMpurity E;Aceclofenac Impurity E（EP）;Aceclofenac IMpurity–E(EP/BP);Ethyl [[[2-[(2,6-Dichlorophenyl)ami;Aceclofenac Impurity 5(Aceclofenac EP Impurity E);Aceclofenac Ethyl (EsterAceclofenac EP Impurity E);Aceclofenac EP Impurity E (Aceclofenac Ethyl Ester);(2-ethoxy-2-oxoethyl) 2-[2-(2,6-dichloroanilino)phenyl]acetate;2-Ethoxy-2-oxoethyl 2-[(2,6-dichlorophenyl)amino]benzeneacetate

CBNumber:: CB72502967

???:: C18H17Cl2NO4

??? ??:: 382.24

MOL ??:: 139272-67-6.mol

?? ?? 73

???????????? ??

???: 70-72°C

?? ?: 460.5±45.0 °C(Predicted)

??: 1.340±0.06 g/cm3(Predicted)

?? ??: -20°C Freezer

???: DMF: 30mg/mL; DMSO: 30mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL; Ethanol: 10mg/mL

??? ??: ??? ??

?? ?? (pKa): -2.84±0.50(Predicted)

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Danger

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H301	??? ???	?? ?? ?? - ??	?? 3	??	P264, P270, P301+P310, P321, P330,P405, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H400	????? ?? ???	?? ????? ?? - ??	?? 1	??	P273, P391, P501
H410	??? ??? ?? ????? ?? ???	?? ????? ?? - ??	?? 1	??	P273, P391, P501

??????:

P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P273	???? ???? ???.
P280	????/???/???/?????? ?????.
P301+P310	???? ?? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P321	(…) ??? ???.
P330	?? ?????.
P332+P313	?? ??? ??? ???? ??· ??? ????.
P391	???? ????.
P405	???? ?????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	0
2		0

???????????? C??? ??, ??, ??

??

Aceclofenac ethyl ester is a potential impurity found in commercial preparations of aceclofenac .

??? ??

White Solid

??

A 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetyl derivative

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???( 73)?? ??

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Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
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CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8647	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11922	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	10983	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323658 +86-18168183658	sales1@artkmedchem.com	China	39002	58

???????????? ?? ??:

DICLOFENAC METHYL ESTER 1-(2,6-Dichlorophenyl)-2-indolinone Aceclofenac Benzyl Ester Aceclofenac Aceclofenac Methyl Ester Diclofenac Ethyl Ester Acetic Aceclofenac IMp. A (EP): [2-[(2,6-Dichlorophenyl)aMino]phenyl]acetic Acid(Diclofenac) Aceclofenac Impurity 5 4'-HYDROXY ACECLOFENAC ACECLOFENAC IMPURITY F Aceclofenac Impurity 4 Aceclofenac tert-butyl ester Aceclofenac-13C2-d4 IMp. I (EP):1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one Diacetic Aceclofenac Aceclofenac Impurity 3 Aceclofenac Impurity 2

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