4'-?????????
|
|
4'-????????? ??
- ???
- 132-135 °C(lit.)
- ?? ?
- 147-148 °C3 mm Hg(lit.)
- ??
- 1.109
- ???
- 0.002Pa at 20℃
- ???
- 1.5577 (estimate)
- ???
- 166 °C
- ?? ??
- Store below +30°C.
- ???
- ???: 0.1 g/mL, ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 8.05(at 25℃)
- Specific Gravity
- 1.109
- ??
- ?? ??~????
- ??
- ????? ??? ? 10.00%. ??? ??? ???? ?? ???
- ?? ??
- ???
- ???
- 10g/L(22℃)
- JECFA Number
- 2040
- BRN
- 774355
- InChIKey
- TXFPEBPIARQUIG-UHFFFAOYSA-N
- LogP
- 1.35 at 25℃
- CAS ??????
- 99-93-4(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-22 | ||
| ????? | 26-36/37-37/39-24/25-22-36 | ||
| WGK ?? | 3 | ||
| RTECS ?? | PC4959775 | ||
| ?? ?? ?? | Irritant | ||
| TSCA | Yes | ||
| HS ?? | 29145000 | ||
| ???? ?? | 2015-3-6897 |
4'-????????? C??? ??, ??, ??
??
? ??? ?? ????? ?? ???, ?????, ?? ? ??? ???? ?????.??
?? ???.??? ??
almost white to beige crystalline powder??
Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort.??
4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.?? ??
Preparation by Fries rearrangement of phenyl acetate with Lewis acidsaluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.
??
ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.?? ??
4'-Hydroxyacetophenone has been suggested for use in perfume compositions as a modifier for the more conventional derivatives of Acetophenonc, etc. mainly in heavy-floral or woodyfloral fragrances where power and low cost arc requested.?? ??
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standardsPurification Methods
Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]4'-????????? ?? ?? ? ???
???
?? ??
4-????-2-???
???????
4-Vinylphenol
????
1-(3-?????-4-?????-??)-???
4-Benzyloxy-3-nitroacetophenone
2-(4-??????)???
1-(4-?????)-3-((?????)??)??)-2-??????
HPG
4-?????-3-???????-(N-??-N-tert?????)????????
4-????? ????
1,1,1-???(4-???????)??
Micafungin????????
3',5'-DICHLORO-4'-HYDROXYACETOPHENONE
4-HYDROXYBENZOYLACETICACID??????
4′-??????????
2-(4-???????)?????
4'-????????? ?? ??
???( 1017)?? ??
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