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150812-13-8
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Retigabine Dihydrochloride
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D 20443;CS-2270;Retigabin.2HCl;Retigabine HCl;Retigabine 2HCL;Retigabine DiHCl;D20443 dihydrochloride;D-20443 dihydrochloride;D 20443 dihydrochloride;Retigabine Dihydrochloride
CBNumber:
CB71565451
???:
C16H20Cl2FN3O2
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376.2
MOL ??:
150812-13-8.mol

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168-170°C
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Hygroscopic, -20°C Freezer, Under Inert Atmosphere
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≥18.8 mg/mL in DMSO; ≥52.4 mg/mL in H2O with gentle warming; ≥8.71 mg/mL in EtOH with gentle warming and ultrasonic
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A new experimental anticonvulsant drug. Anxiolytic.
Retigabine Dihydrochloride (0.1 ~ 10 μM) induced a potassium current and hyperpolarized CHO-KCNQ2/Q3 cells but not in wild-type cells. In the 6-Hz psychomotor seizure model, Retigabine Dihydrochloride dose-dependently blocked seizures induced by either 32 or 44 mA current stimulation.

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