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Trospium chloride

Trospium chloride ??? ???
?? ??:
10405-02-4
???:
Trospium chloride
???(??):
Trospium;Trosupium Chloride;Sanctura;asxvii;keptan;spasmex;spasmo3;relaspium;Spasmo-lyt;trospiuM-D8
CBNumber:
CB6481397
???:
C25H30ClNO3
??? ??:
427.96
MOL ??:
10405-02-4.mol
MSDS ??:
SDS

Trospium chloride ??

???
266-268°C
?? ??
Inert atmosphere,2-8°C
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Solid
??
???? ?????
Merck
14,9786
InChIKey
RVCSYOQWLPPAOA-QKYUOBHYSA-M
SMILES
[N+]12(CCCC1)[C@@]1([H])CC[C@]2([H])C[C@@H](C1)OC(=O)C(O)(C1=CC=CC=C1)C1C=CC=CC=1.[Cl-] |&1:5,9,12,r|
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
RTECS ?? WH1424000
HS ?? 2939800000
?? Soly in water: ~1 g/2 ml. LD50 in mice (mg/kg): 12.3 i.v. (Antweiler)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
??????:
NFPA 704
0
3 0

Trospium chloride MSDS


Trospium chloride

Trospium chloride C??? ??, ??, ??

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Trospium chloride (Sanctura) is an antimuscarinic that has been used in Europe for the management of OAB symptoms for over 30 years.Trospium chloride's chemical structure is such that it is unlikely to penetrate the brain and thus does not appear to affect cognitive function. Trospium chloride is usually administered orally twice a day in 20mg. Trospium chloride should be taken 1 hour before meals or on an empty stomach. It is not well absorbed if taken with food.An advantage of this medication is that it has little potential interaction with other medications.

??? ??

White to Off-White Crystalline Solid

??

Tropine derivative with anticholinergic activity, Trospium chloride can be used as Antispasmodic and used in treatment of urinary incontinence

?? ??

Trospium chloride, 3α-benziloyloxynortropane-8-spiro-1'-pyrrolidinium chloride, (Sanctura) was available in Europe for almost 20 years before gainingapproval in the United States in May 2004. Much likeoxybutynin, it too is a competitive antagonist for muscarinicreceptors and is used to manage overactive bladder. Thequaternary amine reduces the likelihood that this agent willcross the blood-brain barrier. In addition, it has a limitedmetabolic profile, largely a result of its highly water-solublecharacteristics.

Trospium chloride ?? ?? ? ???

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Trospium chloride ?? ??

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Trospium chloride ?? ??:

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