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(+/-)-NFPS???

(+/-)-NFPS???
(+/-)-NFPS??? ??? ???
?? ??:
200006-08-2
???:
(+/-)-NFPS???
???(??):
(+/-)-NFPS???
???:
ALX 5407 Hydrochloride
???(??):
ALX 5407 HYDROCHLORIDE;(+/-)-NFPS HYDROCHLORIDE;N-[3-(4'-FLUOROPHENYL)-3-(4'-PHENYLPHENOXY)PROPYL]SARCOSINE HYDROCHLORIDE;(±)-NFPS hydrochloride, N-[3-(4μ-Fluorophenyl)-3-(4μ-phenylphenoxy)propyl]sarcosine hydrochloride
CBNumber:
CB6363477
???:
C24H25ClFNO3
??? ??:
429.91
MOL ??:
Mol file
MSDS ??:
SDS

(+/-)-NFPS??? ??

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2-8°C
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DMSO: ~16mg/mL, ???
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn,N
?? ???? ?? 22-50/53
????? 22-24/25-61-60
????(UN No.) UN 3077 9 / PGIII
WGK ?? 3
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H410 ??? ??? ?? ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P273 ???? ???? ???.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P391 ???? ????.
P501 ...? ??? / ??? ?? ???.

(+/-)-NFPS??? C??? ??, ??, ??

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ALX 5407 Hydrochloride can be used in the preparation of amino acid derivatives as pharmaceuticals for treatment of neurological and neuropsychiatric disorders.

Biochem/physiol Actions

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).

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(+/-)-NFPS??? ?? ??:

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