5-Fluorouridine
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5-Fluorouridine ??
- ???
- 182-184 °C
- ??
- 17 º (c=2, water 25 ºC)
- ??
- 1.4200 (estimate)
- ???
- 18 ° (C=1, H2O)
- ?? ??
- 2-8°C
- ???
- DMSO(?? 50mg/ml), ?(?? 50mg/ml) ?? ???(?? ? ?? 6mg/ml)? ?????.
- ??? ??
- ??
- ?? ?? (pKa)
- 7.63±0.10(Predicted)
- ??
- ???
- ???? ??
- synthetic (organic)
- ???
- ??
- BRN
- 33662
- ???
- ??? ?? ?????? 1? ?? ??????. DMSO, ??? ?? ???? ??? ??? -20°C?? ?? 3?? ?? ??? ? ????.
- CAS ??????
- 316-46-1(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 40-68-36/37/38 | ||
| ????? | 22-26-36/37-36/37/39-27-24/25 | ||
| WGK ?? | 3 | ||
| RTECS ?? | YU8050000 | ||
| F ?????? | 10 | ||
| ?? ?? ?? | Harmful | ||
| HS ?? | 29349990 |
| ????(GHS): |
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| ?? ?: | Warning | |||||||||||||||||||||
| ??·?? ??: |
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5-Fluorouridine C??? ??, ??, ??
??? ??
White Powder??
5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.??
ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.?? ??
5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.Purification Methods
5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]5-Fluorouridine ?? ?? ? ???
???
?? ??
5-Fluorouridine ?? ??
???( 232)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
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5-Fluorouridine ?? ??:
5-??????? ??? 5-????-2'-??????
5-Fluorouridine
2'-DEOXY-2'-FLUOROURIDINE,2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''- DEOXYURIDINE)
5'-DEOXY-5-FLUOROURIDINE
DMT-2′Fluoro-dU Phosphoramidite
5-Fluoropyrimidine
5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine
2'-DEOXY-5-FLUOROURIDINE, [3H]-
3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE
2',3'-DIDEOXY-3'-FLUOROURIDINE
5'-Deoxy-2',3'-O-isopropylidene-5-fluorouridine
2',3'-dideoxy-5-fluorouridine
5-Fluorouridine
2'-Deoxy-5-fluorouridine 3',5'-dioctanoate
2'-Deoxy-5-fluorouridine 3',5'-dibutanoate
5'-O-(9-Octadecenoyl)-5-fluorouridine