AZD2461
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AZD2461 ??
- ??
- 1.33±0.1 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- insoluble in H2O; ≥16.35 mg/mL in DMSO; ≥45.2 mg/mL in EtOH with ultrasonic
- ?? ?? (pKa)
- 12.07±0.40(Predicted)
- ??? ??
- ??
- ??
- ???? ????
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
AZD2461 C??? ??, ??, ??
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4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one is a phthalazinone derivative and potential PARP inhibitor.Biochem/physiol Actions
AZD2461, an olaparib analog, is an orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters. AZD2461 exhibits a high efficacy in olaparib-resistant tumors that overexpress P-glycoprotein.AZD2461 ?? ?? ? ???
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AZD2461 ?? ??
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