ChemicalBook >?? ???? >4-????????????
4-????????????
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4-???????????? ??
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- 29-33 °C (lit.)
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- 113 °C
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- 224 °F
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- -20°C
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| ?? ???? ?? | 20/21/22-36/37/38 | ||
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| ????? | 26-36/37/39 | ||
| ????(UN No.) | UN 3335 | ||
| WGK ?? | 3 | ||
| ?? ?? | IRRITANT | ||
| HS ?? | 2929900090 |
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4-???????????? C??? ??, ??, ??
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4-Methoxyphenyl isocyanide can be used to synthesize N-(isoquinolin-1-yl)-formamides via reaction with 2-alkynylbenzaldoximes in the presence of silver trifluoromethanesulfonate and bismuth triflate.?? ??
To an ice-cooled flask containing a solution of 10.5 gm (0.065 mole) of p-methoxyformanilide in 37.1 gm (0.47 mole) of pyridine and 13.0 ml (0.16 mole) of chloroform is added dropwise at 0°C 6.12 gm (0.040 mole) of phosphorus oxychloride. The solution is stirred for 1? hr at room temperature and then added to 55 ml of ice-water. The water layer is extracted with two 10-ml portions of chloroform; the combined chloroform layer is dried and distilled under reduced pressure, to afford 3.5 gm (40%), b.p. 767C (1.0 mm Hg), IR 2137 c m " 1 (R—NC).
Synthesis Reference(s)
Journal of Medicinal Chemistry, 38, p. 2955, 1995 DOI: 10.1021/jm00015a0184-???????????? ?? ?? ? ???
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4-???????????? ?? ??:
Benzene, 1-isocyano-2,4-dimethoxy- (9CI)
4-METHOXYPHENYL ISOCYANIDE
Benzene, 4-isocyano-1,2-dimethoxy- (9CI)
6-ISOCYANO-4-OXACHROMANE
4-BENZYLOXYPHENYLISOCYANIDE
1-ISOCYANO-4-PHENOXYBENZENE
1,3-Benzodioxole,5-isocyano-(9CI)
1-CHLORO-5-ISOCYANO-2,4-DIMETHOXYBENZENE
m-Methoxyphenyl isocyanide
o-Methoxyphenyl isocyanide
4-METHOXY-2-METHYL-PHENYLISOCYANIDE
2-NITRO-4-METHOXYPHENYL-ISOCYANIDE
4-OCTYLOXY-PHENYLISOCYANIDE
3,4,5-TRIMETHOXYPHENYL-ISOCYANIDE
2-BROMO-4-TRIFLUOROMETHOXY-PHENYLISOCYANIDE
4-(TRIFLUORMETHOXY)-PHENYLISOCYANIDE
METHYL-2-ISOCYANO-4,5-DIMETHOXY-BENZOATE
4-BUTOXY-PHENYLISOCYANIDE