ChemicalBook >?? ???? >4-???????
4-???????
|
|
4-??????? ??
- ?? ?
- 40.5-44.0 °C(Press: 12 Torr)
- ??
- 1.58 g/cm3(Temp: 25 °C)
- ???
- sol diethyl ether, trifluoroacetic acid, carbon tetrachloride
- ?? ?? (pKa)
- -3.57±0.20(Predicted)
??
4-??????? C??? ??, ??, ??
??
4-chloromorpholine is a useful reagent for selective and efficient chlorination of activated aromatics.Synthesis Reference(s)
1. Smith, J. R. L.; McKeer, L. C.; Taylor, J. M. OSC 1993, 8, 167.2. Smith, J. R. L.; McKeer, L. C.; Taylor, J. M. JCS(P2) 1987, 1533.
Synthesis
4-chloromorpholine is synthesized by Morpholine and aqueous Sodium Hypochlorite at <10 °C, followed by ether extraction, concentration below 30 °C, and vacuum distillation.1,24-??????? ?? ?? ? ???
???
?? ??
4-??????? ?? ??
???( 12)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 |
shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24727 | 58 |
| HBCChem, Inc. | +1-510-219-6317 |
sales@hbcchem.com | United States | 10648 | 60 |
| Aikon International Limited | 025-58851090 13611564524 |
lwan@aikonchem.com | China | 15951 | 58 |
| Hangzhou Bingochem Co., Ltd. | 0571-8512-5372 |
sales@bingochem.com | China | 21669 | 58 |
| Carbosynth | -- |
sales@carbosynth.com | United Kingdom | 6005 | 58 |