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27876-94-4
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???(??):
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Crocetin
???(??):
CROCETIN;TRANS-CROCETIN;NSC407300;a-Crocetin;roceic acid;Alpha-Crocetin;Crocetin (6CI);Stable crocetin;trans-Crocetine;CROCETIN, TRANS-
CBNumber:
CB5780370
???:
C20H24O4
??? ??:
328.4
MOL ??:
27876-94-4.mol
MSDS ??:
SDS

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285°
?? ?
386.14°C (rough estimate)
??
1.0786 (rough estimate)
???
1.4434 (estimate)
FEMA
2998 | SAFFRON (CROCUS SATIVUS L.)
?? ??
Inert atmosphere,Store in freezer, under -20°C
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DMSO(?? ???, ??), ???(?? ???)
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?? ?? (pKa)
4.39±0.19(Predicted)
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LogP
4.312 (est)
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
HS ?? 29171900
????(GHS): GHS hazard pictograms
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?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
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P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.

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Red, rhomboid crystals.Soluble in pyridine and dilute sodium hydroxide; slightly soluble in water and organic solvents. Combustible.

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Experimental treatment of arteriosclerosis by increasing oxygen diffusion through arterial walls, thus decreasing buildup of cholesterol.

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ChEBI: A 20-carbon dicarboxylic acid which is a diterpenoid and natural carotenoid. Found in the crocus flower, it has been administered as an anti-fatigue dietary supplement.

Anticancer Research

It is a natural apocarotenoid dicarboxylic acid obtained from saffron, and saffron isa spice from the flower of the Saffron crocus and present in the dry stigmas of theplant Crocus sativus which can be used as a food colorant. It is reported to be anovel anticancer agent against hepatocellular carcinoma, pancreatic cancer, lungcancer, skin carcinoma, breast cancer, and colorectal cancer. It inhibits the nucleicacid synthesis, enhances antioxidant system, induces apoptosis, hinders growthfactor signaling pathways, and thus affects the growth of cancer cells. It showseffects in the reduction of LPS-induced nitric oxide release; in the reduction ofproduced IL-1β, TNF-α, and intracellular ROS; in the activation of NF-κB; and inthe blockade of LPS (Wang et al. 2012; Gutheil et al. 2012).

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