ChemicalBook >?? ???? >BI 882370

BI 882370

BI 882370 ??? ???

?? ??:: 1392429-79-6

???:: BI 882370

???(??):: CS-2615;BI 882370;BI882370;BI-882370;BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370;1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-;N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide

CBNumber:: CB53358255

???:: C28H33F2N7O2S

??? ??:: 569.67

MOL ??:: 1392429-79-6.mol

?? ?? 41

BI 882370 ??

?? ?: 649.6±65.0 °C(Predicted)

??: 1.37±0.1 g/cm3(Predicted)

?? ??: Store at -20°C

???: DMSO:5.0(Max Conc. mg/mL);8.78(Max Conc. mM)

??? ??: ??? ??

?? ?? (pKa): 5.48±0.10(Predicted)

??: Off-white to gray

??

BI 882370 C??? ??, ??, ??

??

BI-882370 is an orally bioavailable RAF inhibitor with IC₅₀ values of 0.8, 0.8, and 0.6 nM for B-RAF^V600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC₅₀s = 49, 415, 485, 750, 715, and 1,220 nM, respectively). It inhibits proliferation of human B-RAF-mutant melanoma cells when used at concentrations ranging from 1 to 10 nM. It reduces tumor growth in multiple B-RAF-mutant melanoma and colorectal carcinoma mouse xenograft models when administered at a dose of 25 mg/kg twice per day. BI-882370, alone and in combination with trametinib , induces tumor regression in an A375 melanoma mouse xenograft model with no resistance developing within three or five weeks, respectively.

BI 882370 ?? ?? ? ???

???

?? ??

BI 882370 ?? ??

???( 41)?? ??

???	??	???	??	?? ?	??
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38596	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4512	55
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天